Laila Arnesdatter Hopstock
Kaare Harald Bonaa
Anne Elise Eggen
Bjarne K. Jacobsen
Maja-Lisa Loechen, Australian Catholic UniversityFollow
Ellisiv Bøgeberg Mathiesen
Hopstock, L. A, Bonaa, K. H, Eggen, A. E, Grimsgaard, S., Jacobsen, B. K, Loechen, M., Mathiesen, E. B, Njølstad, I. & Wilsgaard, T. (2017). Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016. BMJ Open,7(8), T. Groves. 1-9. United Kingdom: BMJ. Retrieved from https://doi.org/10.1136/bmjopen-2016-015001
Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studies show a cholesterol decline in recent decades but lack data to follow individuals born in different decades throughout life.
We investigated changes in age-specific and birth cohort-specific total cholesterol (TC) levels in 43 710 women and men born in 1905–1977 (aged 20–95 years at screening) in the population-based Tromsø Study. Fifty-nine per cent of the participants had more than one and up to six repeated TC measurements during 1979–2016. Linear mixed models were used to test for time trends.
Mean TC decreased during 1979–2016 in both women and men and in all age groups. The decrease in TC in age group 40–49 years was 1.2 mmol/L in women and 1.0 mmol/L in men. Both the 80th and the 20th percentile of the population TC distribution decreased in both sexes and all age groups. Longitudinal analysis showed that TC increased with age to a peak around middle age followed by a decrease. At any given age, TC significantly decreased with increase in year born. Lipid-lowering drug use was rare in 1994, increased thereafter, but was low ( Conclusions
We found a substantial decrease in mean TC levels in the general population between 1979 and 2016 in all age groups. In birth cohorts, TC increased with age to a peak around middle age followed by a decrease.
Mary MacKillop Institute for Health Research
Open Access Journal Article
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