Walkley, C., Walia, M. K, Ho, P. & Martin, TJ. (2014). PTHrP, its receptor, and protein kinase A activation in osteosarcoma. Molecular & Cellular Oncology,1(4), L. Galluzzi, G. Kroemer. 1-3. United Kingdom: Taylor & Francis. Retrieved from https://doi.org/10.4161/23723548.2014.965624
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.
Mary MacKillop Institute for Health Research
Open Access Journal Article