Hoffman, N J. (2017). Omics and exercise: global approaches for mapping exercise biological networks [accepted manuscript]. Cold Spring Harbor Perspectives in Medicine,7(10), 1-17. Woodbury, United States of America: Cold Spring Harbor Laboratory Press. Retrieved from https://doi.org/10.1101/cshperspect.a029884
The application of global “omics” technologies to exercise has introduced new opportunities to map the complexity and interconnectedness of biological networks underlying the tissue-specific responses and systemic health benefits of exercise. This review will introduce major research tracks and recent advancements in this emerging field, as well as critical gaps in understanding the orchestration of molecular exercise dynamics that will benefit from unbiased omics investigations. Furthermore, significant research hurdles that need to be overcome to effectively fill these gaps related to data collection, computation, interpretation, and integration across omics applications will be discussed. Collectively, a cross-disciplinary physiological and omics-based systems approachwill lead to discovery of a wealth of novel exercise-regulated targets for future mechanistic validation. This frontier in exercise biology will aid the development of personalized therapeutic strategies to improve athletic performance and human health through precision exercise medicine.
Mary MacKillop Institute for Health Research
Open Access Journal Article