Authors
Ester Cerin, Australian Catholic University
Stephanie R. Rainey-Smith
David Ames
Nicola T. Lautenschlager
Stuart Lance Macaulay
Chris J. Fowler
Jane M. Robertson
Christopher C. Rowe
Paul Thomas Maruff
Ralph N. Martins
Colin L. Masters
Kathryn A. Ellis
Publication Date
2017
Publication Details
Cerin, E., Rainey-Smith, S. R, Ames, D., Lautenschlager, N. T, Macaulay, S. L, Fowler, C. J, Robertson, J. M, Rowe, C. C, Maruff, P. T, Martins, R. N, Masters, C. L & Ellis, KA. (2017). Associations of neighborhood environment with brain imaging outcomes in the Australian imaging, biomarkers and lifestyle cohort. Alzheimer's and Dementia,13(4), Z. S. Khachaturian. 388-398. United States: Elsevier Inc.. Retrieved from https://doi.org/10.1016/j.jalz.2016.06.2364
Abstract
Introduction: “Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. Methods: We objectively assessed neighborhood walkability for participants (n 5 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid b burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE ε4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE ε4 carriers) minimally attributable to physical activity.
School/Institute
Mary MacKillop Institute for Health Research
Document Type
Journal Article
Access Rights
ERA Access