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Abstract Introduction and Hypothesis Pelvic floor (PF) dysfunction in patients with cystic fibrosis (CF) is poorly understood due to lack of research. The aim of this study was to examine the prevalence, risk factors and bothersomeness of PF dysfunction and its implications for the clinical management of CF. Methods Of 64 adults with CF approached at a tertiary hospital, 60 were surveyed. A clinically meaningful score on the Australian Pelvic Floor Questionnaire (APFQ) is ≥1 in each of the bladder, bowel, sexual function and prolapse sections or a global PF score of ≥3. A frequency Likert scale was used to analyse the impact of PF dysfunction on the ability to perform physiotherapy lung management when well and unwell. Results The prevalence of clinically meaningful bladder dysfunction was 39%in women and 12%in men, the prevalence of bowel dysfunction was 54 % in women and 44 % in men, and the prevalence of sexual dysfunction was 43 % in women and 65 % in men. APFQ scores were clinically meaningful only for bowel dysfunction in women (median 1.47, IQR 0.59 – 2.28). PF dysfunction constrains lung management in up to 22%of patients when well and in 37%of patients when unwell. Conclusions PF dysfunction affects the adult CF population, with PF symptoms limiting the ability of up to one in three patients to participate in physiotherapy management.

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