Rogers, J. K, McMurray, J., Pocock, S. J, Zannad, F., Krum, H., van Veldhuisen, D. J, Swedberg, K., Shi, H., Vincent, J. & Pitt, B. (2012). Eplerenone in patients with systolic heart failure and mild symptoms: Analysis of repeat hospitalizations. Circulation,126(19), 2317-2323. United States: Lippincott Williams & Wilkins. Retrieved from https://doi.org/10.1161/CIRCULATIONAHA.112.110536
Eplerenone is known to reduce time to first hospitalization for heart failure or cardiovascular death in patients with heart failure and mild symptoms. In chronic diseases such as heart failure, characterized by repeat hospitalizations, analyzing all heart failure hospitalizations, not just the first, should give a more complete picture of treatment benefits.
Mary MacKillop Institute for Health Research