Authors
Zee Upton
Hilary J. Wallace
Gary K. Shooter
Derek R. van Lonkhuyzen
Sim Yeoh-Ellerton
Erin A. Rayment
Jacqui M. Fleming
Daniel Broszczak, Australian Catholic UniversityFollow
Douglas Queen
R. Gary Sibbald
David I. Leavesley
Michael C. Stacey
Publication Date
2011
Publication Details
Upton, Z., Wallace, H. J, Shooter, G. K, van Lonkhuyzen, D. R, Yeoh-Ellerton, S., Rayment, E. A, Fleming, J. M, Broszczak, D., Queen, D., Sibbald, R. G, Leavesley, D. I & Stacey, MC. (2011). Human pilot studies reveal the potential of a vitronectin: Growth factor complex as a treatment for chronic wounds. International Wound Journal,8(5), 522-532. United Kingdom: Blackwell Publishing Inc.. Retrieved from https://doi.org/10.1111/j.1742-481X.2011.00859.x
Abstract
Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high costs have limited their widespread adoption. Many treatments have ignored the evidence that wound healing is driven by interactions between extracellular matrix proteins and GFs, not just GFs alone. We report herein that a clinical Good Manufacturing Practice-grade vitronectin:growth factor (cVN:GF) complex is able to stimulate functions relevant to wound repair in vitro, such as enhanced cellular proliferation and migration. Furthermore, we assessed this complex as a topical wound healing agent in a single-arm pilot study using venous leg ulcers, as well as several ‘difficult to heal’ case studies. The cVN:GF complex was safe and re-epithelialisation was observed in all but 1 of the 30 patients in the pilot study. In addition, the case studies show that this complex may be applied to several ulcer aetiologies, such as venous leg ulcers, diabetic foot ulcers and pressure ulcers. These findings suggest that further evaluation is warranted to determine whether the cVN:GF complex may be an effective topical treatment for chronic wounds.
Document Type
Journal Article
Access Rights
ERA Access