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Background: We sought to determine the overall impact of a nurse: led, multidisciplinary home: based intervention ( HBI ) adapted to hospitalized patients with chronic forms of heart disease of varying types. Methods and Results: Prospectively planned, combined, secondary analysis of 3 randomized trials ( 1226 patients ) of HBI were compared with standard management. Hospitalized patients presenting with heart disease but not heart failure, atrial fibrillation but not heart failure, and heart failure, as well, were recruited. Overall, 612 and 614 patients, respectively, were allocated to a home visit 7 to 14 days postdischarge by a cardiac nurse with follow: up and multidisciplinary support according to clinical need or standard management. The primary outcome of days: alive and out: of: hospital was examined on an intention: to: treat basis. During 1371 days ( interquartile range, 1112–1605 ) of follow: up, 218 patients died and 17 917 days of hospital stay were recorded. In comparison with standard management, HBI patients achieved significantly prolonged event: free survival ( 90.1% [95% confidence interval, 88.2–92.0] versus 87.2% [95% confidence interval, 85.1–89.3] days: alive and out: of: hospital; P=0.020 ). This reflected less all: cause mortality ( adjusted hazard ratio, 0.67; 95% confidence interval, 0.50–0.88; P=0.005 ) and unplanned hospital stay ( median, 0.22 [interquartile range, 0–1.3] versus 0.36 [0–2.1] days/100 days follow: up; P=0.011 ). Analyses of the differential impact of HBI on all: cause mortality showed significant interactions ( characterized by U: shaped relationships ) with age ( P=0.005 ) and comorbidity ( P=0.041 ); HBI was most effective for those aged 60 to 82 years ( 59%–65% of individual trial cohorts ) and with a Charlson Comorbidity Index Score of 5 to 8 ( 36%–61% ). Conclusions: These data provide further support for the application of postdischarge HBI across the full spectrum of patients being hospitalized for chronic forms of heart disease. Clinical Trial Registration: URL: Unique identifiers: 12610000221055, 12608000022369, 12607000069459.


Mary MacKillop Institute for Health Research

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Open Access Journal Article

Access Rights

Open Access


© 2016 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.