Keedwell, P. A, Chapman, R., Christiansen, K., Richardson, H., Evans, J. & Jones, DK. (2012). Cingulum white matter in young women at risk of depression: The effect of family history and anhedonia. Biological Psychiatry,72(4), 296-302. United States: Elsevier BV. Retrieved from https://doi.org/10.1016/j.biopsych.2012.01.022
Background: Altered white matter microstructure in tracts integral to mood regulation networks could underlie vulnerability to major depressive disorder (MDD). Guided by functional magnetic resonance studies, we explored whether a positive family history of MDD (FH ) and anhedonia (reduced capacity for pleasure) were associated with altered white matter microstructure in the cingulum bundles and uncinate fasciculi.
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