McMurray, J J. (2011). CONSENSUS to EMPHASIS: The overwhelming evidence which makes blockade of the reninangiotensinaldosterone system the cornerstone of therapy for systolic heart failure. European Journal of Heart Failure,13(9), 929-936. United Kingdom: John Wiley & Sons Ltd.. Retrieved from https://doi.org/10.1093/eurjhf/hfr093
We will shortly celebrate the 25th anniversary of the publication of the Co-operative North Scandinavian Enalapril Survival Study ( CONSENSUS ), a clinical trial which revolutionized the treatment of heart failure and highlighted the importance of the renin–angiotensin–aldosterone system ( RAAS ) in the pathophysiology of heart failure ( Figure 1 ). In this article I will give a brief, historical overview of this exciting quarter-century of discovery related to the RAAS. My focus is on the treatment of heart failure in patients with a low left ventricular ejection fraction.
Mary MacKillop Institute for Health Research
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