Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years : Results from a national, population-based prospective study (the Australian diabetes, obesity and lifestyle study)
Gagnon, C., Lu, Z., Magliano, D., Dunstan, D., Shaw, J., Zimmet, P., Sikaris, K., Grantham, N., Ebeling, P. & Daly, R. (2011). Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years : Results from a national, population-based prospective study (the Australian diabetes, obesity and lifestyle study). Diabetes Care,34(5), 1133-1138. Retrieved from https://doi.org/10.2337/dc10-2167
Objective: To examine whether serum 25-hydroxyvitamin D (25OHD) and dietary calcium predict incident type 2 diabetes and insulin sensitivity. Research design and methods: A total of 6,537 of the 11,247 adults evaluated in 1999–2000 in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study, returned for oral glucose tolerance test (OGTT) in 2004–2005. We studied those without diabetes who had complete data at baseline (n = 5,200; mean age 51 years; 55% were women; 92% were Europids). Serum 25OHD and energy-adjusted calcium intake (food frequency questionnaire) were assessed at baseline. Logistic regression was used to evaluate associations between serum 25OHD and dietary calcium on 5-year incidence of diabetes (diagnosed by OGTT) and insulin sensitivity (homeostasis model assessment of insulin sensitivity [HOMA-S]), adjusted for multiple potential confounders, including fasting plasma glucose (FPG).