Cooper, D., Ahamed, Y., Macdonald, H. & McKay, H. (2008). Characterising cortical density in the mid-tibia : Intra-individual variation in adolescent girls and boys. British Journal of Sports Medicine,42(8), 690-695. Retrieved from https://doi.org/10.1136/bjsm.2008.049528
Background: Inter-individual differences in cortical bone volumetric density (CoD), such as those related to sex, are a product of differences in remodelling rates. While cortical bone is often treated as a uniform tissue, remodelling rates also vary within individual bones. This level of adaptation has largely been overlooked in analyses of peripheral quantitative computed tomography (pQCT) images. Further, such variation in CoD has never been assessed in growing bones. We hypothesised that CoD varied significantly within the same cross-section of the mid-tibia of adolescents. We further hypothesised that due to the profound impact of oestrogen on remodelling, this variation would be different between sexes.
Mary MacKillop Institute for Health Research
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