Anuradha, H., Lally, J., Galic, S., Thomas, M., Azizi, P., Fullerton, M., Smith, B., Pulinilkunnil, T., Chen, Z., Samaan, M., Jorgensen, S., Hawke, T. & Van Dender. (2014). Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic asian population. Investigative Ophthalmology & Visual Science,57(8), 1693-1702. Retrieved from https://doi.org/10.1167/iovs.11-7324
Aims/hypothesis: Obesity is characterised by lipid accumulation in skeletal muscle, which increases the risk of developing insulin resistance and type 2 diabetes. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status and is activated in skeletal muscle by exercise, hormones (leptin, adiponectin, IL-6) and pharmacological agents (5-amino-4-imidazolecarboxamide ribonucleoside [AICAR] and metformin). Phosphorylation of acetyl-CoA carboxylase 2 (ACC2) at S221 (S212 in mice) by AMPK reduces ACC activity and malonyl-CoA content but the importance of the AMPK–ACC2–malonyl-CoA pathway in controlling fatty acid metabolism and insulin sensitivity is not understood; therefore, we characterised Acc2 S212A knock-in (ACC2 KI) mice.
Mary MacKillop Institute for Health Research