Zadow, E. K, Adams, M. J, Wu, S. S, Kitic, C. M, Singh, I., Kundur, A., Bost, N., Johnston, A. N, Crilly, J., Bulmer, A. C, Halson, S. L & Fell, JW. (2018). Compression socks and the effects on coagulation and fibrinolytic activation during marathon running. European Journal of Applied Physiology,118(10), 2171-2177. Germany: Springer. Retrieved from https://doi.org/10.1007/s00421-018-3929-5
Purpose Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer. Results Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI. Conclusions While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.
School of Exercise Science