Publication Date



Background Chronic venous leg ulcers (VLUs) are costly to the healthcare system and a burden to patients, significantly reducing quality of life. Nitric oxide (NO) is important to wound healing, with a small study demonstrating a NO donor, topical glyceryl trinitrate (GTN), was effective for VLU healing. The aim of this study is to examine the application of topical GTN in relation to VLU healing.
Methods A pilot double-blinded randomised controlled clinical trial will be undertaken. Participants in the control group (n=20) will receive a placebo ointment (ointment base) and participants in the treatment group (n=20) will receive a NO donor (base ointment with 2% GTN) weekly for 4 weeks. The inclusion criteria will be adults >18 years of age with a chronic VLU. Rate of healing will be determined by planimetry (ulcer tracing) using the Gillman equation.
Significance This clinical trial aims to provide proof of concept of a novel treatment, topical GTN, which may accelerate wound healing through improvements to vasodilation and antimicrobial properties at the wound bed.
What is already known

  • Chronic VLUs are a burden to patients and the healthcare system.
  • NO is important to wound healing.
  • GTN is a NO donor.
What this study aims to contribute
  • Pilot a double-blind clinical trial of topical GTN.
  • Examine the effect of 2% topical GTN on wound healing in VLUs.


School of Nursing, Midwifery & Paramedicine

Document Type

Open Access Journal Article

Access Rights

Open Access

Included in

Nursing Commons