Dewamitta, S. R, Joseph, C., Purton, L. E & Walkley, CR. (2013). Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors. British Journal of Haematology,164(2), 280-285. United Kingdom: Wiley-Blackwell. Retrieved from https://doi.org/10.1111/bjh.12578
Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ‐line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ−/− mice were anaemic, however, Epor‐Cre Rarafl/fl, Epor‐Cre Rargfl/fl and Epor‐Cre Rarafl/flgfl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid‐specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.
Mary MacKillop Institute for Health Research
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