Risk factors of female breast cancer in Vietnam: a case-control study

Phuong D.Y. Trieu
Claudia Mello-Thoms
Jennifer Peat
Thuan D. Do
P. Brennan

Abstract

Purpose: Rates of women with breast cancer have increased rapidly in recent years in Vietnam, with over 10,000 new patients contracting the disease every year. This study was conducted to identify demographic, reproductive and lifestyle risk factors for breast cancer in Vietnam. Materials and Methods: Breast density, demographic, reproductive and lifestyle data of 269 women with breast cancer and 519 age-matched controls were collected in the two largest oncology hospitals in Vietnam (one in the north and one in the south). Baseline differences between cases and controls in all women, premenopausal and postmenopausal women were assessed using chi-squared tests and independent t tests. Conditional logistic regression was used to derive odds ratios (OR) for factors that had statistically significant associations with breast cancer. Results: Vietnamese women with breast cancer were significantly more likely to have a breast density > 75% (OR, 1.7), be younger than 14 years at first menstrual period (OR, 2.2), be postmenopausal (OR, 2.0), have less than three pregnancies (OR, 2.1), and have less than two babies (OR, 1.7). High breast density (OR, 1.6), early age at first menstrual period (OR, 2.6), low number of pregnancies (OR, 2.3), hormone use (OR, 1.8), and no physical activities (OR, 2.2) were significantly associated with breast cancer among premenopausal women, while breast density (OR, 2.0), age at first menstrual period (OR, 1.8), number of pregnancies (OR, 2.3), and number of live births (OR, 2.4) were the risk factors for postmenopausal women. Conclusion: Breast density, age at first menarche, menopause status, number of pregnancies, number of babies born, hormone use and physical activities were significantly associated with breast cancer in Vietnamese women.