Date of Submission
Tomcik, K. A. (2016). Effects of creatine availability on skeletal muscle metabolism (Doctoral thesis, Australian Catholic University). Retrieved from https://doi.org/10.4226/66/5a9dbb3733622
Nutritional strategies which increase energy substrate availability enhance exercise capacity and affect cell signalling and muscle morphology. The co-ingestion of carbohydrate with creatine has been shown to enhance both intramuscular creatine as well as glycogen storage, with the former being thoroughly investigated with respect to resistance-based exercise. Despite evidence of synergy, the direct performance benefits of this co-supplementation strategy on endurance-based exercise and its metabolic effect(s) on cellular signalling remained to be investigated. The work comprising this thesis represents a series of independent yet related studies that determined the effects of manipulating creatine along with carbohydrate (glucose) and/or insulin availability using both in vivo (human) and in vitro (rodent cell lines) models to better understand creatine‘s role in metabolism and performance.
Mary MacKillop Institute for Health Research
Doctor of Philosophy (PhD)
Faculty of Health Sciences