The Mary MacKillop Institute for Health Research aims to identify critical gaps within community and healthcare services, with an explicit goal to improve health outcomes (and a focus on vulnerable groups) via innovative individual, community and health service-focused programs.

Collaborating on projects nationally and internationally, The MacKillop invests in people and communities across Australia and beyond its borders.

Through research that responds to real needs, researchers are working to improve the well-being of people locally and globally so that they can lead full, healthy lives.

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Submissions from 2017

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Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: Analysis of the CHARMPreserved and I-Preserve trials, Azmil H. Abdul-Rahim, Ana-Cristina Perez, Rachael L. Macisaac, Pardeep S. Jhund, Brian L. Claggett, Peter E. Carson, Michel Komajda, Robert S. McKelvie, Michael R. Zile, Karl Swedberg, Salim Yusuf, Marc A. Pfeffer, Scott D. Solomon, Gregory Y. H. Lip, Kennedy R. Lees, and John J. V. McMurray

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Low YKL-40 in chronic heart failure may predict beneficial effects of statins: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA), Fizza Arain, Lars Gullestad, Ståle Nymo, John Kjekshus, John G. Cleland, Annika Michelsen, John J. McMurray, John Wikstrand, Pål Aukrust, and Thor Ueland

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Updated risk factors should be used to predict development of diabetes, Mary Angelyn Bethel, Kristen A. Hyland, Antonio R. Chacra, Prakash Deedwania, Gregory R. Fulcher, Rury R. Holman, Trond Jenssen, Naomi S. Levitt, John J. V. McMurray, Eleni Boutati, Laine Thomas, Jie-Lena Sun, and Steven M. Haffner

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Thirty years of evidence on the efficacy of drug treatments for chronic heart failure with reduced ejection fraction: A network meta-analysis, Heather Burnett, Amy Earley, Adriaan A. Voors, Michele Senni, John McMurray, Celine Deschaseaux, and Shannon Cope

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Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction, Jane A. Cannon, Li Shen, Pardeep S. Jhund, Søren L. Kristensen, Lars Kober, Fabian Chen, Jianjian Gong, Martin P. Lefkowitz, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, and John J. V. McMurray

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Psychometric Testing of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI), Victoria Dickson, Christopher Lee, Karen S. Yehle, Ana Mola, Kenneth M. Faulkner, and Barbara Riegel

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How robust are clinical trials in heart failure?, Kieran F. Docherty, Ross T. Campbell, Pardeep S. Jhund, Mark C. Petrie, and John J. V. McMurray

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International variation in outcomes among people with cardiovascular disease or cardiovascular risk factors and impaired glucose tolerance: Insights from the NAVIGATOR trial, Marilia Harumi Higuchi Dos Santos, Abhinav Sharma, Jie Lena Sun, Karen Pieper, John J.V. McMurray, Rury R. Holman, and Renato D. Lopes

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Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales), Connor A. Emdin, Allan J. Hsiao, Amit Kiran, Nathalie Conrad, Gholamreza Salimi-Khorshidi, Mark Woodward, Simon G. Anderson, Hamid Mohseni, John J.V. McMurray, John G. F. Cleland, H. J. Dargie, Suzanna Hardman, Theresa McDonagh, and Kazem Rahimi

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Prognostic value of insulin-like growth factor-binding protein 7 in patients with heart failure and preserved ejection fraction, Parul U. Gandhi, Sheryl L. Chow, Thomas S. Rector, Henry Krum, Hanna K. Gaggin, John J. V. McMurray, Michael R. Zile, Michel Komajda, Robert S. McKelvie, Peter E. Carson, James L. Januzzi, and Inder S. Anand

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Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men, Stefan H. M. Gorissen, Nicholas A. Burd, Irene Fleur Kramer, Janneau van Kranenburg, Annemie P. Gijsen, Olav Rooyackers, and Luc J. C. van Loon

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B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review, Nathaniel M. Hawkins, Amit Khosla, Sean A. Virani, John J.V. McMurray, and J. Mark FitzGerald

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Psychometric analysis of the heart failure somatic perception scale as a measure of patient symptom perception, Corrine Y. Jurgens, Christopher S. Lee, and Barbara Riegel

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Objective snoring time and carotid intima-media thickness in non-apneic female snorers, Jinyoung Kim, Allan I. Pack, Barbara J. Riegel, Julio A. Chirinos, Alexandra Hanlon, Seung Ku Lee, and Chol Shin

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Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: Insights from the ASCEND-HF trial, Takeshi Kitai, Justin L. Grodin, Robert J. Mentz, Adrian F. Hernandez, Javed Butler, Marco Metra, John J. V. McMurray, Paul W. Armstrong, Randall C. Starling, Christopher M. O'Connor, Karl Swedberg, and W. H. Wilson Tang

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Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction: A report from the I-Preserve Trial (Irbesartan in heart failure with preserved ejection fraction), Søren L. Kristensen, Ulrik M. Mogensen, Pardeep Jhund, Mark C. Petrie, David Preiss, Sithu Win, Lars Kober, Robert McKelvie, Michael R. Zile, Inder S. Anand, Michel Komajda, John S. Gottdiener, Peter E. Carson, and John McMurray

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Comparison of contemporaneous responses for EQ-5D-3L and Minnesota living with heart failure; A case for disease specific multiattribute utility instrument in cardiovascular conditions, Sanjeewa Kularatna, Joshua Byrnes, Yih Kai Chan, Melinda Jane Carrington, Simon Stewart, and Paul A. Scuffham

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The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF, Ulrik M. Mogensen, Lars Kober, Søren L. Kristensen, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Sweberg, Michael R. Zile, Scott D. Solomon, Milton Packer, and John J.V. McMurray

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Team Rwanda: Will Africans dominate professional road cycling in the future?, Jean Nyakayiru, Lex B. Verdijk, Naomi M. Cermak, and Luc J. C. van Loon

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Limited added value of circulating inflammatory biomarkers in chronic heart failure, Ståle H. Nymo, Pål Aukrust, John Kjekshus, John J.V. McMurray, John G. F. Cleland, John Wikstrand, Pieter Muntendam, Ursula Henrike Wienhues-Thelen, Roberto Latini, Erik Tandberg Askevold, Jørgen Gravning, Christen P. Dahl, Kaspar Broch, Arne Yndestad, Lars Gullestad, and Thor Ueland

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Aldosterone does not predict cardiovascular events following acute coronary syndrome in patients initially without heart failure, Reynaria Pitts, Elise Gunzburger, Christie M. Ballantyne, Philip J. Barter, David Kallend, Lawrence A. Leiter, Eran Leitersdorf, Stephen J. Nicholls, Prediman K. Shah, Jean-Claude Tardif, Anders G. Olsson, John J.V. McMurray, John Kittelson, and Gregory G. Schwartz

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Mechanisms of change in self-care in adults with heart failure receiving a tailored, motivational interviewing intervention, Barbara Riegel, Victoria Dickson, Lydia Elena Garcia, Ruth Masterson Creber, and Megan Streur

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Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: A post-hoc analysis from the PARADIGM-HF trial, Jelena P. Seferovic, Brian L. Claggett, Sara B. Seidelmann, Ellen W. Seely, Milton Packer, Michael R. Zile, Jean L. Rouleau, Karl Swedberg, Martin P. Lefkowitz, Victor C. Shi, Akshay S. Desai, John J. V. McMurray, and Scott D. Solomon

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The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism, Alexander Tacey, Lewan Parker, Andrew Garnham, Tara C. Brennan-Speranza, and Itamar Levinger

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MOTIVATional intErviewing to improve self-care in Heart Failure patients (MOTIVATE-HF): Study protocol of a three-arm multicenter randomized controlled trial, Ercole Vellone, Marco Paturzo, Fabio D'Agostino, Antonio Petruzzo, Stefano Masci, Davide Ausili, Paola Rebora, Rosaria Alvaro, and Barbara Riegel

Submissions from 2016

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Efficacy and safety of digoxin in patients with heart failure and reduced ejection fraction according to diabetes status: An analysis of the Digitalis Investigation Group (DIG) trial, Azmil H. Abdul-Rahim, Rachael L. MacIsaac, Pardeep S. Jhund, Mark C. Petrie, Kennedy R. Lees, and John J.V. McMurray

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The clinical course of health status and association with outcomes in patients hospitalized for heart failure: Insights from ASCEND-HF, Andrew P. Ambrosy, Adrian F. Hernandez, Paul W. Armstrong, Javed Butler, Allison Dunning, Justin A. Ezekowitz, G. Michael Felker, Stephen J. Greene, Padma Kaul, John J. V. McMurray, Marco Metra, Christopher M. O'Connor, Shelby D. Reed, Phillip J. Schulte, Randall C. Starling, W. H. Wilson Tang, Adriaan A. Voors, and Robert J. Mentz

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Traditional and new composite endpoints in heart failure clinical trials: Facilitating comprehensive efficacy assessments and improving trial efficiency, Stefan D. Anker, Stefan Schroeder, Dan Atar, Jeroen J. Bax, Claudio Ceconi, Martin R. Cowie, Adam Crisp, Fabienne Dominjon, Ian Ford, Hossein-Ardeschir Ghofrani, Savion Gropper, Gerhard Hindricks, Mark A. Hlatky, Richard Holcomb, Narimon Honarpour, J. Wouter Jukema, Albert M. Kim, Michael Kunz, Martin P. Lefkowitz, Chantal Le Floch, Ulf Landmesser, Theresa A. McDonagh, John J. V. McMurray, Bela Merkely, Milton Packer, Krishna Prasad, James Revkin, Giuseppe M. C. Rosano, Ransi Somaratne, Wendy Gattis Stough, Adriaan A. Voors, and Frank Ruschitzka

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Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity, Sarah J. Annesley, Sui T. Lay, Shawn W. De Piazza, Oana Sanislav, Eleanor Hammersley, Claire Y. Allan, Lisa M. Francione, Minh Q. Bui, Zhi-Ping Chen, Kevin R. W. Ngoei, Flora Tassone, Bruce E. Kemp, Elsdon Storey, Andrew Evans, Danuta Z. Loesch, and Paul R. Fisher

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Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States, Melina Arnold, Heinz Freisling, Rachael Stolzenberg-Solomon, Frank Kee, Mark George O'Doherty, José Manuel Ordóñez-Mena, Tom Wilsgaard, Anne Maria May, Hendrik Bas Bueno-de-Mesquita, Anne Tjønneland, Philippos Orfanos, Antonia Trichopoulou, Paolo Boffetta, Freddie Bray, Mazda Jenab, Isabelle Soerjomataram, Migle Baceviciene, Jolanda M. A. Boer, Wojciech Drygas, Sture Eriksson, Edith Feskens, Valeriy Gafarov, Julian Gardiner, Niclas Hakansson, Jan-Hakkan Jansson, Pekka Jousilahti, Ellen Kampman, Jukka Kontto, Ruzena Kubinova, Max Leenders, Allan Linneberg, Maja-Lisa Loechen, Roberto Lorbeer, Sofia Malyutina, Ellisiv Bøgeberg Mathiesen, Hakan Melhus, Karl Michaëlsson, Inger Njølstad, Nicola Orsini, Andrzej Pajak, Hynek Pikhart, Charlotta Pisinger, Veikko Salomaa, Maria-Jose Sanchez, Susana Sans, Barbara Schaan, Andrea Schneider, Galatios Siganos, Stefan Soderberg, Martinette Streppel, Abdonas Tamosiunas, Giovanni Veronesi, Eveline Waterham, and Patrik Wennberg

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Protein intake and lean body mass preservation during energy intake restriction in overweight older adults, E. M. P. Backx, Michael Tieland, Karin J. Borgonjen-Van Den Berg, P. R. Claessen, Lucas Van Loon, and Lisette C.P.G.M. de Groot

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Metformin prevents nigrostriatal dopamine degeneration independent of AMPK activation in dopamine neurons, Jacqueline A. Bayliss, Moyra B. Lemus, Vanessa Santos, Minh Deo, Jeffrey S. Davies, Bruce Ernest Kemp, John D. Elsworth, and Zane B. Andrews

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Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial, Kim L. Bennell, Yasmin Ahamed, Gwendolen J. Jull, Christina Bryant, Michael A. Hunt, Andrew B. Forbes, Jessica Kasza, Muhammed Akram, Ben R. Metcalf, Anthony Harris, T. Egerton, Justin A. Kenardy, Michael K. Nicholas, and Francis J. Keefe

Doping in sport and exercise: Anabolic, ergogenic, health and clinical issues, Stephen R. Bird, Catrin Goebel, Louise Mary Burke, and Ronda F. Greaves

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Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students, Audrey L. Blewer, Jiaqi Li, Daniel J. Ikeda, Marion Leary, David G. Buckler, Barbara Riegel, Sunita Desai, Peter W. Groeneveld, Mary E. Putt, and Benjamin S. Abella

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Video-only cardiopulmonary resuscitation education for high-risk families before hospital discharge: A multicenter pragmatic trial, Audrey L. Blewer, Mary E. Putt, Lance B. Becker, Barbara Riegel, Jiaqi Li, Marion Leary, Judy A. Shea, James N. Kirkpatrick, Robert A. Berg, Vinay M. Nadkarni, Peter W. Groeneveld, and Benjamin S. Abella

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Clinical outcomes according to QRS duration and morphology in the Irbesartan in Patients with Heart Failure and Preserved Systolic Function (I-PRESERVE) trial, Jane A. Cannon, Li Shen, Pardeep S. Jhund, Inder S. Anand, Michel Komajda, Robert S. McKelvie, Michael R. Zile, Peter E. Carson, and John J. V. McMurray

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Continuous-time semi-Markov models in health economic decision making: An illustrative example in heart failure disease management, Qi Cao, Erik Buskens, Talitha Feenstra, Tiny Jaarsma, Hans L. Hillege, and Douwe Postmus

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Temporal trends in incidence and case fatality of intracerebral hemorrhage: The Tromsø Study 1995-2012, Maria Carlsson, Tom Wilsgaard, Stein Harald Johnsen, Anne Merete Vangen-Lønne, Maja-Lisa Løchen, Inger Njølstad, and Ellisiv Bøgeberg Mathiesen

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Current and projected burden of heart failure in the Australian adult population: A substantive but still ill-defined major health issue, Yih-Kai Chan, Camilla Tuttle, Jocasta Clare Ball, Tiew-Hwa Katherine Teng, Yasmin Ahamed, Melinda Jane Carrington, and Simon Stewart

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Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: An analysis of the EMPHASIS-HF study, Ken Lee Chin, Timothy J. Collier, Bertram Pitt, John J. V. McMurray, Karl Swedberg, Dirk J. van Veldhuisen, Stuart J. Pocock, John Vincent, Eva Turgonyi, Faiez Zannad, and Henry Krum

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Thoracic and lumbar posture behaviour in sitting tasks and standing: Progressing the biomechanics from observations to measurements, Andrew P. Claus, Julie Anne Hides, G. Lorimer Moseley, and Paul W. Hodges

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Accuracy of anxiety and depression screening tools in heart transplant recipients, Aaron William Conway, Judith Sheridan, Joanne Maddicks-Law, Paul Richard Fulbrook, Chantal Ski, David Robert Thompson, and Lynn V. Doering

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Predictors and associations with outcomes of length of hospital stay in patients with acute heart failure: Results from VERITAS, Gad Cotter, Beth A. Davison, Olga Milo, Robert C. Bourge, John G. F. Cleland, Guillaume Jondeau, Henry Krum, Christopher M. O'Connor, Marco Metra, John D. Parker, Guillermo Torre-Amione, Dirk J. van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J. V. McMurray, and John R. Teerlink

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Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction, Kevin Damman, John Kjekshus, John Wikstrand, John G. F. Cleland, Michel Komajda, Hans Wedel, Finn Waagstein, and John J. V. McMurray

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Worsening renal function and outcome in heart failure patients with reduced and preserved ejection fraction and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme, Kevin Damman, Scott D. Solomon, Marc A. Pfeffer, Karl Swedberg, Salim Yusuf, James B. Young, Jean L. Rouleau, Christopher B. Granger, and John J. V. McMurray

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Sitting less and moving more: Improved glycaemic control for type 2 diabetes prevention and management, Paddy C. Dempsey, Neville Owen, Thomas E. Yates, Bronwyn A. Kingwell, and David Wayne Dunstan

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Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization, Akshay S. Desai, Brian L. Claggett, Milton Packer, Michael R. Zile, Jean L. Rouleau, Karl Sweberg, Victor Shi, Martin Lefkowitz, Randall Starling, John Teerlink, John J.V. McMurray, and Scott D. Solomon

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Factors associated with noncompletion during the run-in period before randomization and influence on the estimated benefit of LCZ696 in the PARADIGM-HF trial, Akshay S. Desai, Scott Solomon, Brian L. Claggett, John McMurray, Jean L. Rouleau, Karl Swedberg, Michael Zile, Martin P. Lefkowitz, Victor C. Shi, and Milton Packer

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Prevalence, incidence, risk factors and treatment of atrial fibrillation in Australia: The Australian Diabetes, Obesity and Lifestyle (AusDiab) longitudinal, population cohort study, Ibrahima Diouf, Dianna J. Magliano, Melinda Jane Carrington, Simon Stewart, and Jonathan E. Shaw

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A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion, Marlou L. Dirks, Benjamin T. Wall, Irene Fleur Kramer, Antoine H. Zorenc, Joy P. B. Goessens, Annemie P. Gijsen, and Luc J. C. Van Loon

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One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation, Marlou L. Dirks, Benjamin T. Wall, Bas van de Valk, Tanya M. Holloway, Graham P. Holloway, Adrian Chabowski, Gijs H. Goossens, and Luc J. C. van Loon

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Symptom trajectory and symptom burden in older people with multimorbidity, secondary outcome from the RCT AGe-FIT study, Jeanette Eckerblad, Kersti Theander, Anne W. Ekdahl, and Tiny Jaarsma

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SnapShot: Exercise metabolism, Brendan Egan, John Alan Hawley, and Juleen R. Zierath

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Long-Term Evaluation of the Ambulatory Geriatric Assessment: A Frailty Intervention Trial (AGe-FIT): Clinical Outcomes and Total Costs After 36 Months, Anne W. Ekdahl, Jenny Alwin, Jeanette Eckerblad, Magnus Husberg, Tiny Jaarsma, Amelie Lindh Mazya, Anna Milberg, Barbro Krevers, Mitra Unosson, Rolf Wiklund, and Per Carlsson

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Variation in hospital performance for heart failure management in the National Heart Failure Audit for England and Wales, Connor A. Emdin, Nathalie Conrad, Amit Kiran, Gholamreza Salimi-Khorshidi, Mark Woodward, Simon G. Anderson, Hamid Mohseni, Henry J. Dargie, Suzanna M. C. Hardman, Theresa McDonagh, John J. V. McMurray, John G. F. Cleland, and Kazem Rahimi

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Constipation in specialized palliative care: Factors related to constipation when applying different definitions, Eva Erichsen, Anna Milberg, Tiny Jaarsma, and Maria J. Friedrichsen

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The Muscle Metabolome Differs between Healthy and Frail Older Adults, Parastoo Fazelzadeh, Roland W. J. Hangelbroek, Michael Tieland, Lisette C. P. G. M. de Groot, Lex B. Verdijk, Luc J.C. Van Loon, Age K. Smilde, Rodrigo D. A. M. Alves, Jacques Vervoort, Michael Müller, John P. M. van Duynhoven, and Mark V. Boekschoten

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Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives, João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A. Pfeffer, John J. V. McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A. Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J. Wouter Jukema, John G. Cleland, Faiez Zannad, and Patrick Rossignol

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Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion compared with glucose ingestion in trained athletes, Cas J. Fuchs, Javier T. Gonzalez, Milou Beelen, Naomi M. Cermak, Fiona E. Smith, Pete E. Thelwall, Roy Taylor, Michael I. Trenell, Emma J. Stevenson, and Luc J. C. van Loon

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Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children, Leigh Gabel, Nicola D. Ridgers, P. A. Della Gatta, Lauren Arundell, Ester Cerin, Sally Robinson, Rob Daly, David Wayne Dunstan, and Jo Salmon

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Liver glycogen metabolism during and after prolonged endurance-type exercise, Javier T. Gonzalez, Cas J. Fuchs, James A. Betts, and Luc J. C. Van Loon

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Increasing insulin availability does not augment postprandial muscle protein synthesis rates in healthy young and older men, Bart B. L. Groen, Astrid M. H. Horstman, Henrike M. Hamer, Michiel de Haan, Janneau van Kranenburg, Jörgen Bierau, Martijn Poeze, Will K. W. H. Wodzig, Blake B. Rasmussen, and Luc J. C. van Loon

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Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment, Nathaniel M. Hawkins, Pardeep S. Jhund, Andrea Pozzi, Eileen O'Meara, Scott D. Solomon, Christopher B. Granger, Salim Yusuf, Marc A. Pfeffer, Karl Swedberg, Mark C. Petrie, Sean A. Virani, and John J. V. McMurray

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Metabolism: One step forward for exercise, John Alan Hawley and Anna Krook

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Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial, Hiddo J. L. Heerspink, T. Ninomiya, Frederik Persson, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, A. S. Desai, S. M. Haffner, John J. V. McMurray, S. D. Solomon, M. A. Pfeffer, Hans-Henrik Parving, and D. de Zeeuw

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Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men, Andrew M. Holwerda, Imre W. K. Kouw, Jorn Trommelen, Shona L. Halson, Will K. W. H. Wodzig, Lex B. Verdijk, and Luc J. C. van Loon

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Associations of Low-and High-Intensity Light Activity with Cardiometabolic Biomarkers, Patrick Howard, Kylie Smith, Fabienne Else, and Ellie Crookes

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Burden of diarrhea in the Eastern Mediterranean Region, 1990-2013: Findings from the Global Burden of Disease Study 2013, Khalil Ibrahim, Danny V. Colombara, Mohammad Hossein Forouzanfar, Christopher Troeger, Farah Daoud, Maziar Moradi-Lakeh, Charbel El Bcheraoui, Puja C. Rao, Ashkan Afshin, Raghid Charara, Kalkidan Hassen Abate, Mohammed Magdy Abd El Razek, Foad Abd-Allah, Remon Abu-Elyazeed, Aliasghar Ahmad Kiadaliri, Ali Shafqat Akanda, Nadia Akseer, Khurshid Alam, Deena Alasfoor, Raghib Ali, Mohammad A. Al Mazroa, Mahmoud A. Alomari, Rajaa Mohammad Salem Al-Raddadi, Ubai Alsharif, Shirina Alsowaidi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Walid Ammar, Carl Abelardo T. Antonio, Hamid Asayesh, Rana Jawad Asghar, Suleman Atique, Ashish Awasthi, Umar Bacha, Alaa Badawi, Aleksandra Barac, Neeraj Bedi, Tolesa Bekele, Isabela M. Bensenor, Balem Demtsu Betsu, Zulfiqar Bhutta, Aref A. Bin Abdulhak, Zahid A. Butt, Hadi Danawi, Manisha Dubey, Aman Yesuf Endries, Imad D. A. Faghmous, Talha Farid, Maryam S. Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Joseph Robert Anderson Fitchett, Katherine B. Gibney, Ibrahim Abdelmageem Mohamed Ginawi, Melkamu Dedefo Gishu, Harish Chander Gugnani, Rahul Gupta, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Hilda L. Harb, Mohammad T. Hedayati, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Mehdi Javanbakht, Tariku Jibat, Jost B. Jonas, Amir Kasaeian, Yousef Saleh Khader, Abdur Rahman Khan, Ejaz Ahmad Khan, Gulfaraz Khan, Tawfik Ahmed Muthafer Khoja, Yohannes Kinfu, Niranjan Kissoon, Ai Koyanagi, Aparna Lal, Asma Abdul Abdul Latif, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Alem Mehari, Alemayehu B. Mekonnen, Yohannes Adama Melaku, Ziad A. Memish, Walter Mendoza, Awoke Misganaw, Layla Abdalla Ibrahim Mohamed, Jean B. Nachega, Quyen Le Nguyen, Muhammad Imran Nisar, Emmanuel Kwame Peprah, James A. Platts-Mills, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M. Rana, Chhabi L. Ranabhat, Sowmya R. Rao, Amany H. Refaat, Mark Riddle, Gholamreza Roshandel, George Mugambage Ruhago, Muhammad Muhammad Saleh, Juan R. Sanabria, Monika Sawhney, Sadaf G. Sepanlou, Tesfaye Setegn, Karen Sliwa, Chandrashekhar T. Sreeramareddy, Bryan L. Sykes, Mohammad Tavakkoli, Bemnet Amare Tedla, Abdullah S. Terkawi, Kingsley Ukwaja, Olalekan A. Uthman, Ronny Westerman, Mamo Wubshet, Muluken A. Yenesew, Naohiro Yonemoto, Mustafa Z. Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Abdullah A. Al Rabeeah, Haidong Wang, Mohsen Naghavi, Theo Vos, Alan D. Lopez, Christopher J. L. Murray, and Ali H. Mokdad

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The incremental prognostic and clinical value of multiple novel biomarkers in heart failure, Colette E. Jackson, Caroline Haig, Paul Welsh, Jonathan R. Dalzell, Ioannis K. Tsorlalis, Alex McConnachie, David Preiss, Stefan D. Anker, Naveed Sattar, Mark C. Petrie, Roy S. Gardner, and John J. V. McMurray

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Nitrate-rich vegetables increase plasma nitrate and nitrite concentrations and lower blood pressure in healthy adults, Kristin L. Jonvik, Jean Nyakayiru, Philippe J. M. Pinckaers, Joan M. G. Senden, Luc J. C. van Loon, and Lex B. Verdijk

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Habitual Dietary Nitrate Intake in Highly Trained Athletes, Kristin L. Jonvik, Jean Nyakayiru, Jan Willem van Dijk, Floris C. Wardenaar, Lucas Van Loon, and Lex B. Verdijk

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Cardiac Troponin T and i Release after a 30-km Run, Lieke J. J. Klinkenberg, Peter Luyten, Noreen Van Der Linden, Kim Urgel, Daniëlle P. C. Snijders, Christian Knackstedt, Robert Dennert, Bastiaan L. J. H. Kietselaer, Alma M. A. Mingels, Eline P. M. Cardinaels, Frederique E. C. M. Peeters, Jeroen D. E. Van Suijlen, Joop Ten Kate, Elke Marsch, Thomas L. Theelen, Judith C. Sluimer, Kristiaan Wouters, Otto Bekers, Sebastiaan C. A. M. Bekkers, Luc Van Loon, Marja P. Van Dieijen-Visser, and Steven J. R. Meex

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Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction, Lieke J. J. Klinkenberg, Karin Wildi, Noreen Van Der Linden, Imre W. K. Kouw, Marijke Niens, Raphael Twerenbold, Maria Rubini Gimenez, Christian Puelacher, Jean Daniel Neuhaus, Petra Hillinger, Thomas Nestelberger, Jasper Boeddinghaus, Karin Grimm, Zaid Sabti, Judith A. P. Bons, Jeroen D. E. Van Suijlen, Frans E. S. Tan, Joop Ten Kate, Otto Bekers, Luc Van Loon, Marja P. Van Dieijen-Visser, Christian Mueller, and Steven J. R. Meex

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Sexual counseling in patients with heart failure: A silent phenomenon: Results from a convergent parallel mixed method study, Nina Kolbe, Christiane Kugler, Wilfried Schnepp, and Tiny Jaarsma

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Sexual counseling in patients with heart failure: A silent phenomenon: Results from a convergent parallel mixed method study, Nina Kolbe, Christiane Kugler, Wilfried Schnepp, and Tiny Jaarsma

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Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients, Imre W. K. Kouw, Naomi M. Cermak, Nicholas A. Burd, Tyler A. Churchward-Venne, Joan M. Senden, Annemie P. Gijsen, and Luc J. C. van Loon

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Geographic variations in the PARADIGM-HF heart failure trial, Søren L. Kristensen, Felipe Martinez, Pardeep S. Jhund, Juan Luis Arango, Jan Bĕlohlávek, Sergey Boytsov, Walter Cabrera, Efrain Gomez, Albert Alain Hagege, Jun Huang, Songsak Kiatchoosakun, Kee-Sik Kim, Iván Mendoza, Michele Senni, Iain B. Squire, Dragos Vinereanu, Raymond Chiew-Chiew Wong, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, and John J. V. McMurray

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Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: Insights from prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial, Søren L. Kristensen, David Preiss, Pardeep Jhund, Iain Squire, Jose Silva Cardoso, Bela Merkely, Felipe Martinez, Randall C. Starling, Akshay S. Desai, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, S. D. Solomon, Karl Swedberg, Michael R. Zile, John McMurray, and Milton Packer

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Short message service (SMS) as an educational tool during pregnancy: A literature review, Kim Lamont, Karen Sliwa, Simon Stewart, Melinda Jane Carrington, Sandra Pretorius, Elena Libhaber, Charles S. Wiysonge, Esther F. Adebayo, and Kerstin Klipstein-Grobusch

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Predicting outcomes over time in patients with heart failure, left ventricular systolic dysfunction, or both following acute myocardial infarction, Renato D. Lopes, Karen S. Pieper, Susanna R. Stevens, Scott D. Solomon, John J.V. McMurray, Marc A. Pfeffer, Jeffrey D. Leimberger, and Eric J. Velazquez

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Unique correlates of heart failure and cancer caregiver satisfaction with hospice care, Meredith A. Mackenzie, Harleah G. Buck, Salimah H. Meghani, and Barbara Riegel

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Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population, Jan Mannsverk, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Maja-Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, and Kaare Harald Bønaa

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Practical approach on frail older patients attended for acute heart failure, Francisco J. Martín-Sánchez, Michael Christ, Òscar Miró, W. Frank Peacock, John J. McMurray, Héctor Bueno, Alan S. Maisel, Louise Cullen, Martin R. Cowie, Salvatore Di Somma, Elke Platz, Joseph Masip, Uwe Zeymer, Christiaan Vrints, Susanna Price, and Christian Mueller

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Determinants of behavioral alertness in adults with heart failure, Ruth Masterson Creber, Victoria M. Pak, Miranda Varrasse, David F. Dinges, Joyce Wald, and Barbara Riegel

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Motivational interviewing to improve self-care for patients with chronic heart failure: MITI-HF randomized controlled trial, Ruth Masterson Creber, Megan Patey, C. Lee, Amy Kuan, Corrine Y. Jurgens, and Barbara Riegel

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C-Reactive Protein and Risk of ESRD: Results From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT), Finnian R. McCausland, Brian L. Claggett, Emmanuel A. Burdmann, Kai Uwe Eckardt, Reshma Kewalramani, Andrew S. Levey, John McMurray, Patrick Parfrey, Guiseppe Remuzzi, Ajay K. Singh, Scott Solomon, Robert D. Toto, and Marc A. Pfeffer

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Aliskiren, enalapril, or aliskiren and enalapril in heart failure, John J. V. McMurray, Henry Krum, William T. Abraham, Kenneth Dickstein, Lars V. Kober, Akshay S. Desai, Scott D. Solomon, Nicola Greenlaw, M. Atif Ali, Yanntong Chiang, Qing Shao, Georgia Tarnesby, and Barry M. Massie

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Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial), Marco Metra, Robert J. Mentz, Adrian F. Hernandez, Gretchen M. Heizer, P. W. Armstrong, Nadine Clausell, Ramon Corbalan, Maria Rosa Costanzo, Kenneth Dickstein, Mark E. Dunlap, Justin A. Ezekowitz, Jonathan G. Howlett, Michel Komajda, Henry Krum, Carlo Lombardi, Gregg C. Fonarow, John J. V. McMurray, Markku S. Nieminen, Karl Swedberg, Adriaan A. Voors, Randall C. Starling, John R. Teerlink, and Christopher M. O'Connor

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Depressive symptoms, cardiac anxiety, and fear of body sensations in patients with non-cardiac chest pain, and their relation to healthcare-seeking behavior: A cross-sectional study, Ghassan Mourad, Anna Stromberg, Peter Johansson, and Tiny Jaarsma

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Effects of sacubitril/valsartan in the PARADIGM-HF trial (prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure) according to background therapy, Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, and John McMurray

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Importance of clinical worsening of heart failure treated in the outpatient setting: Evidence from the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF), Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, and John McMurray

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Rationale for and design of the TRUE-AHF trial: The effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure, Milton Packer, Richard Holcomb, William T. Abraham, Stefan D. Anker, Kenneth Dickstein, Gerasimos S. Filippatos, Henry Krum, Aldo Pietro Maggioni, John J. V. McMurray, Alexandre Mebazaa, Christopher M. O'Connor, Frank Peacock, Piotr P. Ponikowski, Frank Ruschitzka, Dirk J. van Veldhuisen, and Johannes Holzmeister

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Increased mortality with elevated plasma endothelin-1 in acute heart failure: An ASCEND-HF biomarker substudy, Antonio L. Perez, Justin L. Grodin, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan A. Voors, John J. V. McMurray, Paul W. Armstrong, Randall C. Starling, Christopher M. O'Connor, and W. H. Wilson Tang

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Lessons in uncertainty and humility - Clinical trials involving hypertension, Marc A. Pfeffer and John J. V. McMurray

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2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by represe, Massimo F. Piepoli, Arno W. Hoes, Stefan Agewall, Christian Albus, Carlos Brotons, Alberico L. Catapano, Marie Therese Cooney, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Michael Stephen Hall, F. D. Richard Hobbs, Maja-Lisa Loechen, Herbert Löllgen, Pedro Marques-Vidal, Joep Perk, Eva Prescott, Josep Redon, Dimitrios J. Richter, Naveed Sattar, Yvo Smulders, Monica Tiberi, H. Bart van der Worp, Ineke van Dis, and W. M. Monique Verschuren

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2016 European guidelines on Cardiovascular Diseases prevention in clinical practice the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Diseases Prevention in Clinical Practice (constituted by representatives of 10 societies and invited experts), Massimo F. Piepoli, Arno W. Hoes, Stefan Agewall, Christian Albus, Carlos Brotons, Alberico L. Catapano, Marie-Therese Cooney, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Michael Stephen Hall, F. D. Richard Hobbs, Maja-Lisa Loechen, Herbert Löllgen, Pedro Marques-Vidal, Joep Perk, Eva Prescott, Josep Redon, Dimitrios J. Richter, Naveed Sattar, Yvo Smulders, Monica Tiberi, H. Bart van der Worp, Ineke van Dis, W. M. Monique Verschuren, Guy De Backer, Marco Roffi, Victor Aboyans, Norbert Bachl, Héctor Bueno, Scipione Carerj, Leslie Cho, John Cox, Johan De Sutter, Günther Egidi, Miles Fisher, Donna Fitzsimmons, Oscar H. Franco, Maxime Guenoun, Catriona Jennings, Borut Jug, Paulus Kirchhof, Kornelia Kotseva, Gregory Y.H. Lip, Francois Mach, Giuseppe Mancia, Franz Martin Bermudo, Alessandro Mezzani, Alexander Niessner, Piotr Ponikowski, Bernhard Rauch, Lars Ryden, Adrienne Stauder, Guillaume Turc, Olov Wiklund, Stephan Windecker, and Jose Luis Zamorano

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Telerehabilitation in heart failure patients: The evidence and the pitfalls, Ewa Piotrowicz, Massimo F. Piepoli, Tiny Jaarsma, Ekaterini Lambrinou, Andrew J. S. Coats, Jean-Paul Schmid, Ugo Corra, Piergiuseppe Agostoni, Kenneth Dickstein, Petar M. Seferovic, Stamatis Adamopoulos, and Piotr P. Ponikowski

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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Gailure of the European Society of Cardiology (ESC), Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland, Andrew J. S. Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Parissis, Burkert Pieske, Jillian P. Riley, Giuseppe M. C. Rosano, Luis Miguel Ruilope, Frank Ruschitzka, Frans H. Rutten, Peter van der Meer, Gerasimos S. Filippatos, John. J. V. McMurray, Victor Aboyans, Stephan Achenbach, Stefan Agewall, Nawwar Al-Attar, John J. Atherton, Johann Bauersachs, A. John Camm, Scipione Carerj, Claudio Ceconi, Antonio Coca, Perry Elliott, Çetin Erol, Justin A. Ezekowitz, Covadonga Fernández-Golfín, Donna Fitzsimmons, Marco Guazzi, Maxime Guenoun, Gerd Hasenfuss, Gerhard Hindricks, Arno W. Hoes, Bernard Iung, Tiny Jaarsma, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Stavros Konstantinides, Mitja Lainscak, Patrizio Lancellotti, Gregory Y. H. Lip, Francesco Maisano, Christian Mueller, Mark C. Petrie, Massimo F. Piepoli, Silvia G. Priori, Adam Torbicki, Hiroyuki Tsutsui, Dirk J. van Veldhuisen, Stephan Windecker, Clyde Yancy, and Jose Luis Zamorano

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Is there any gender difference for smoking persistence or relapse following diagnosis or hospitalization for coronary heart disease? Evidence from a systematic review and meta-analysis, Muhammad Aziz Rahman, Karen-Leigh Edward, Laura Montgomery, Samantha Marie McEvedy, Andrew Wilson, and Linda Worrall-Carter