Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration

Journal article


Tachtsis, Bill, Camera, Donny and Lacham-Kaplan, Orly. (2018). Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration. Nutrients. 10(3), pp. 1 - 20. https://doi.org/10.3390/nu10030309
AuthorsTachtsis, Bill, Camera, Donny and Lacham-Kaplan, Orly
Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are commonly found in fish oil supplements, are known to possess anti-inflammatory properties and more recently alter skeletal musclefunction. In this review, we discuss novel findings related to how n-3 PUFAs modulate molecular signaling responsible for growth and hypertrophy as well as the activity of muscle stem cells. Muscle stem cells commonly known as satellite cells, are primarily responsible for driving the skeletal muscle repair process to potentially damaging stimuli, such as mechanical stress elicited by exercise contraction. To date, there is a paucity of human investigations related to the effects of n-3 PUFAs on satellite cell content and activity. Based on current in vitro investigations, this review focuses on novel mechanisms linking n-3 PUFA’s to satellite cell activity and how they may improve muscle repair. Understanding the role of n-3 PUFAs during muscle growth and regeneration in association with exercise could lead to the development of novel supplementation strategies that increase muscle mass and strength, therefore possibly reducing the burden of muscle wasting with age.

Keywordsageing; Omega-3; satellite cells; skeletal muscle
Year2018
JournalNutrients
Journal citation10 (3), pp. 1 - 20
PublisherMDPI AG
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu10030309
Scopus EID2-s2.0-85043310921
Page range1 - 20
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
EditorsJ. Buckley
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Hayes, Eric, Galea, Sandra, Verkuylen, Amanda, Pera, Martin, Morrison, John, Lacham-Kaplan, Orly and Trounson, Alan. (2001). Nuclear transfer of adult and genetically modified fetal cells of the rat. Physiological Genomics. 5(4), pp. 193 - 203.
Pregnancies produced from fertile and infertile stallions by intracytoplasmic sperm injection (ICSI) of single frozen-thawed spermatozoa into in vivo matured mare oocytes.
McKinnon, A. O., Lacham-Kaplan, Orly and Trounson, Alan. (2000). Pregnancies produced from fertile and infertile stallions by intracytoplasmic sperm injection (ICSI) of single frozen-thawed spermatozoa into in vivo matured mare oocytes. Reproduction: Supplement.
Developmental competence of nuclear transfer cow oocytes after direct injection of fetal fibroblast nuclei
Lacham-Kaplan, Orly, Diamente, Maria, Pushett, David, Lewis, Ian and Trounson, Alan. (2000). Developmental competence of nuclear transfer cow oocytes after direct injection of fetal fibroblast nuclei. Cloning. 2(2), pp. 55 - 62. https://doi.org/10.1089/152045500436078
Intracytoplasmic sperm injection, zona drilling and zona removal of the human oocyte and embryo
Okuma, Y., Lacham-Kaplan, Orly and Trounson, Alan. (1998). Intracytoplasmic sperm injection, zona drilling and zona removal of the human oocyte and embryo. Zygote. 6(Supplement 1), pp. 51 - 51.
Is the acrosome reaction a prerequisite for sperm incorporation after intra-cytoplasmic sperm injection (ICSI)?
Sathananthan, A. H., Szell, A., Ng, S. C., Kausche, A., Lacham-Kaplan, Orly and Trounson, Alan. (1997). Is the acrosome reaction a prerequisite for sperm incorporation after intra-cytoplasmic sperm injection (ICSI)? Reproduction Fertility and Development. 9(7), pp. 703 - 709. https://doi.org/10.1071/R97028
Fertilization and embryonic developmental capacity of epididymal and testicular sperm and immature spermatids and spermatocytes
Lacham-Kaplan, Orly and Trounson, Alan. (1997). Fertilization and embryonic developmental capacity of epididymal and testicular sperm and immature spermatids and spermatocytes. Reproductive Medicine Review. 6(1), pp. 55 - 68.
Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching
Barnes, Frank L., Crombie, Amanda, Gardner, David K., Kausche, A., Lacham-Kaplan, Orly, Suikkari, Anne Maria, Tiglias, Jennifer, Wood, Carl and Trounson, Alan. (1995). Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching. Human Reproduction. 10(12), pp. 3243 - 3247. https://doi.org/10.1093/oxfordjournals.humrep.a135896
Intracytoplasmic sperm injection in mice: Increased fertilization and development to term after induction of the acrosome reaction
Lacham-Kaplan, Orly and Trounson, Alan. (1995). Intracytoplasmic sperm injection in mice: Increased fertilization and development to term after induction of the acrosome reaction. Human Reproduction. 10(10), pp. 2642 - 2649. https://doi.org/10.1093/oxfordjournals.humrep.a135760
Embryo development capacity of oocytes fertilized by immature sperm and sperm treated with motility stimulants
Lacham-Kaplan, Orly and Trounson, Alan. (1994). Embryo development capacity of oocytes fertilized by immature sperm and sperm treated with motility stimulants. Reproduction Fertility and Development. 6(1), pp. 113 - 116. https://doi.org/10.1071/RD9940113
Microinjection: Choice of embryo transfer technique
McLachlan, Robert I., Fuscaldo, Giuliana, Calderon, Ilan, Lacham-Kaplan, Orly, Poulos, Christine, Rho, Hwan, Trounson, Alan and Wood, Carl. (1994). Microinjection: Choice of embryo transfer technique. Reproduction Fertility and Development. 6(1), pp. 57 - 61. https://doi.org/10.1071/RD9940057
The effects of the sperm motility activators 2-deoxyadenosine and pentoxifylline used for sperm micro-injection on mouse and human embryo development
Lacham-Kaplan, Orly and Trounson, Alan. (1993). The effects of the sperm motility activators 2-deoxyadenosine and pentoxifylline used for sperm micro-injection on mouse and human embryo development. Human Reproduction. 8(6), pp. 945 - 952. https://doi.org/10.1093/oxfordjournals.humrep.a138172
Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure
Sakkas, D., Lacham-Kaplan, Orly, Gianaroli, Luca and Trounson, Alan. (1992). Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure. Fertility and Sterility. 57(6), pp. 1279 - 1288.
Fertilizing capacity of epididymal and testicular spermatozoa microinjected under the zona pellucida of the mouse oocyte
Lacham-Kaplan, Orly and Trounson, Alan. (1991). Fertilizing capacity of epididymal and testicular spermatozoa microinjected under the zona pellucida of the mouse oocyte. Molecular Reproduction and Development. 29(1), pp. 85 - 93. https://doi.org/10.1002/mrd.1080290113
Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space
Kola, Ismail, Lacham-Kaplan, Orly, Jansen, Robert P. S., Turner, Marie and Trounson, Alan. (1990). Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space. Human Reproduction. 5(5), pp. 575 - 577. https://doi.org/10.1093/oxfordjournals.humrep.a137147
Fertilization and development of mouse eggs injected under the zona pellucida with single spermatozoa treated to induce the acrosome reaction
Lacham-Kaplan, Orly, Trounson, Alan, Holden, Carol, Mann, Jeff and Sathananthan, Henry. (1989). Fertilization and development of mouse eggs injected under the zona pellucida with single spermatozoa treated to induce the acrosome reaction. Gamete Research. 23(2), pp. 233 - 243. https://doi.org/10.1002/mrd.1120230210
Fertilization of mouse and human eggs by microinjection of single spermatozoa under the zona pellucida.
Trounson, Alan, Peura, A. and Lacham-Kaplan, Orly. (1989). Fertilization of mouse and human eggs by microinjection of single spermatozoa under the zona pellucida. Reproduction: Supplement. 38, pp. 145 - 152.