Scott, D., Shore-Lorenti, C., McMillan, L. B, Mesinovic, J., Clark, R., Hayes, A., Sanders, K., Duque, G. & Ebeling, P. (2018). Calf muscle density in independently associated with physical function in overweight and obese older adults. The Journal of Musculoskeletal and Neuronal Interactions,18(1), G. P. Lyritis. 9-17. Greece: The International Society of Musculoskeletal and Neuronal Interactions.
Objectives: To determine whether associations of calf muscle density with physical function are independent of other determinants of functional decline in overweight and obese older adults. Methods: This was a secondary analysis of a cross-sectional study of 85 community-dwelling overweight and obese adults (mean±SD age 62.8±7.9 years; BMI 32.3±6.1 kg/m2; 58% women). Peripheral quantitative computed tomography assessed mid-calf muscle density (66% tibial length) and dual-energy X-ray absorptiometry determined visceral fat area. Fasting glucose, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and C-reactive protein (CRP) were analysed. Physical function assessments included hand grip and knee extension strength, balance path length (computerised posturography), stair climb test, Short Physical Performance Battery (SPPB) and self-reported falls efficacy (Modified Falls Efficacy Scale; M-FES). Results: Visceral fat area, not muscle density, was independently associated with CRP and fasting glucose (B=0.025; 95% CI 0.009-0.042 and B=0.009; 0.001-0.017, respectively). Nevertheless, higher muscle density was independently associated with lower path length and stair climb time, and higher SPPB and M-FES scores (all P < 0.05). Visceral fat area, fasting glucose and CRP did not mediate these associations. Conclusions: Higher calf muscle density predicts better physical function in overweight and obese older adults independent of insulin resistance, visceral adiposity or inflammation. © 2018, International Society of Musculoskeletal and Neuronal Interactions.
Mary MacKillop Institute for Health Research
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