CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study

Journal article


Tiwari, Sweta, Loechen, Maja-Lisa, Jacobsen, Bjarne K., Hopstock, Laila Arnesdatter, Nyrnes, Audhild, Njolstad, Inger, Mathiesen, Ellisiv Bøgeberg and Schirmer, Henrik. (2016). CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study. Open Heart. 3(2), pp. 1 - 8. https://doi.org/10.1136/openhrt-2016-000439
AuthorsTiwari, Sweta, Loechen, Maja-Lisa, Jacobsen, Bjarne K., Hopstock, Laila Arnesdatter, Nyrnes, Audhild, Njolstad, Inger, Mathiesen, Ellisiv Bøgeberg and Schirmer, Henrik
Abstract

Objective: CHA2DS2-VASc score, left atrial (LA) size and atrial fibrillation (AF) have individually been associated with stroke risk. Our aim was to investigate the predictive ability of combinations of these factors for the odds of incident stroke in a population-based cohort study. Methods: We followed 2844 participants from the Tromsø Study from 1994 to 2012. Information on LA size and CHA2DS2-VASc score (age, sex, congestive heart failure, hypertension, vascular disease, stroke and diabetes) were obtained at baseline. AF status was recorded from medical records. The outcome measure was all strokes. The association between covariates and stroke was investigated by means of multivariate logistic regression analysis. Results: A total of 325 participants (45% women, mean age at baseline 59.3 years) had a stroke. Incidence rates for stroke were 6.4 in women and 8.4 in men per 1000 person-years. Participants with CHA2DS2-VASc ≥1 and LA size < 2.8 had ∼4 times (95% CI 2.6 to 5.3) increased odds of stroke, whereas participants with CHA2DS2-VASc ≥1 and LA size ≥2.8 had ∼9 times (95% CI 5.3 to 16.4) increased odds of stroke, compared with participants with CHA2DS2-VASc score 0, irrespective of AF status. Adjustment for significant covariates had minimal impact on the OR estimates. Conclusions: Combining CHA2DS2-VASc score ≥1 and enlarged LA size identified participants with high odds of stroke regardless of AF status.

Year2016
JournalOpen Heart
Journal citation3 (2), pp. 1 - 8
PublisherB M J Group
ISSN2053-3624
Digital Object Identifier (DOI)https://doi.org/10.1136/openhrt-2016-000439
Scopus EID2-s2.0-84986332686
Open accessOpen access
Page range1 - 8
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Place of publicationUnited Kingdom
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https://acuresearchbank.acu.edu.au/item/850xv/cha2ds2-vasc-score-left-atrial-size-and-atrial-fibrillation-as-stroke-risk-factors-in-the-troms-study

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