A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders

Journal article


Andrews, Jessica L. and Fernandez, Francesca Elizabeth. (2015). A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neuroscience and Biobehavioral Reviews. 56, pp. 97 - 114. https://doi.org/10.1016/j.neubiorev.2015.06.009
AuthorsAndrews, Jessica L. and Fernandez, Francesca Elizabeth
Abstract

Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the potential application of Lingo-1 as a therapeutic target for the treatment of neurological disorders has so far been under-estimated. A number of preclinical studies have shown that various methods of antagonizing Lingo-1 results in neuronal and oligodendroglial survival, axonal growth and remyelination; however to date literature has only detailed applications of Lingo-1 targeted therapeutics with a focus primarily on myelination disorders such as multiple sclerosis and spinal cord injury; omitting important information regarding Lingo-1 signaling co-factors. Here, we provide for the first time a complete and thorough review of the implications of Lingo-1 signaling in a wide range of neurological and psychiatric disorders, and critically examine its potential as a novel therapeutic target for these disorders.

Keywordslingo-1 signaling; gene expression; neurological pathologies; psychiatric disorders; therapeutic strategies
Year2015
JournalNeuroscience and Biobehavioral Reviews
Journal citation56, pp. 97 - 114
PublisherPergamon Press
ISSN0149-7634
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neubiorev.2015.06.009
Page range97 - 114
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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