Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients

Journal article


van Dijk, Jan-Willem, Manders, Ralph J. F., Hartgens, Fred, Stehouwer, Coen D. A., Praet, Stephan F. E. and van Loon, Luc J. C.. (2011). Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Research and Clinical Practice. 93(1), pp. 31 - 37. https://doi.org/10.1016/j.diabres.2011.03.021
Authorsvan Dijk, Jan-Willem, Manders, Ralph J. F., Hartgens, Fred, Stehouwer, Coen D. A., Praet, Stephan F. E. and van Loon, Luc J. C.
Abstract

Aim: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions. Methods: 60 male type 2 diabetes patients (HbA1c 7.5 ± 0.1% [58 ± 1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. Results: Type 2 diabetes patients experienced hyperglycemia (glucose concentrations > 10 mmol/L) 38 ± 4% of the day. Even diabetes patients with an HbA1c level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24 ± 5% throughout the day. Hyperglycemia was negligible in the control group (3 ± 1%). Conclusion: Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA1c level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.

Keywordstype 2 diabetes mellitus; postprandial hyperglycemia; normal glucose tolerance; glycemic control; continuous glucose monitoring
Year2011
JournalDiabetes Research and Clinical Practice
Journal citation93 (1), pp. 31 - 37
PublisherElsevier Ireland Ltd.
ISSN0168-8227
Digital Object Identifier (DOI)https://doi.org/10.1016/j.diabres.2011.03.021
Scopus EID2-s2.0-79960563297
Open accessOpen access
Page range31 - 37
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Additional information

© 2011 Elsevier Ireland Ltd. Open access under the Elsevier OA license.

Place of publicationIreland
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