Langerdorf, C. G & Kemp, BE. (2015). Choreography of AMPK activation. Cell Research,25(1), 5-6. United Kingdom: Nature Publishing Group. Retrieved from https://doi.org/10.1038/cr.2014.163
A recent study published in Cell Research by Li and colleagues reports a detailed biophysical and structural study of AMPK's intra-molecular interactions during activation. By employing subunit tagging and proximity analysis with the aid of AlphaScreen instrumentation, Li et al. add to our understanding of the choreography of activation of AMPK by both nucleotides and phosphorylation.
Mary MacKillop Institute for Health Research
Access may be restricted.