Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: Secondary analysis of a randomized, double-blind, placebo-controlled trial

Journal article


Van De Rest, Ondine, Van Der Zwalu, Nikita L., Tieland, Michael, Adam, Jos J., Hiddink, Gert Jan, Van Loon, Luc J.C. and de Groot, Lisette C. P. G. M.. (2014). Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: Secondary analysis of a randomized, double-blind, placebo-controlled trial. Mechanisms of Ageing and Development. 136-137, pp. 85 - 93. https://doi.org/10.1016/j.mad.2013.12.005
AuthorsVan De Rest, Ondine, Van Der Zwalu, Nikita L., Tieland, Michael, Adam, Jos J., Hiddink, Gert Jan, Van Loon, Luc J.C. and de Groot, Lisette C. P. G. M.
Abstract

Physical activity has been proposed as one of the most effective strategies to prevent cognitive decline. Protein supplementation may exert an additive effect. The effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly people was assessed in a secondary analysis. Two 24-week, double-blind, randomized, placebo-controlled intervention studies were carried out in parallel. Subjects performed a resistance-type exercise program of two sessions per week (n = 62) or no exercise program (n = 65). In both studies, subjects were randomly allocated to either a protein (2 15 g daily) or a placebo drink. Cognitive functioning was assessed with a neuropsychological test battery focusing on the cognitive domains episodic memory, attention and working memory, information processing speed, and executive functioning. In frail and pre-frail elderly, resistance-type exercise training in combination with protein supplementation improved information processing speed (changes in domain score 0.08 0.51 versus 0.23 0.19 in the non-exercise group, p = 0.04). Exercise training without protein supplementation was beneficial for attention and working memory (changes in domain scores 0.35 0.70 versus 0.12 0.69 in the non-exercise group, p = 0.02). There were no significant differences among the intervention groups on the other cognitive tests or domain scores. 20

KeywordsFrailty; Aging; Cognitive functioning; Exercise training; Protein supplementation
Year2014
JournalMechanisms of Ageing and Development
Journal citation136-137, pp. 85 - 93
PublisherElsevier Ireland Ltd.
ISSN0047-6374
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mad.2013.12.005
Scopus EID2-s2.0-84899954916
Page range85 - 93
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationIreland
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