A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

Journal article

Barker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group. (2016). A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22(4), pp. 297-301. https://doi.org/10.1136/injuryprev-2015-041655
AuthorsBarker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group
Abstract

Background: Disability, mortality and healthcare burden from fractures in older people is a growing problem worldwide. Observational studies suggest that aspirin may reduce fracture risk. While these studies provide room for optimism, randomised controlled trials are needed. This paper describes the rationale and design of the ASPirin in Reducing Events in the Elderly ( ASPREE )-Fracture substudy, which aims to determine whether daily low-dose aspirin decreases fracture risk in healthy older people.

Methods: ASPREE is a double-blind, randomised, placebo-controlled primary prevention trial designed to assess whether daily active treatment using low-dose aspirin extends the duration of disability-free and dementia-free life in 19 000 healthy older people recruited from Australian and US community settings. This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged ≥70 years recruited in Australia. The intervention is a once daily dose of enteric-coated aspirin ( 100 mg ) versus a matching placebo, randomised on a 1:1 basis. The primary outcome for this substudy is the occurrence of any fracture—vertebral, hip and non-vert-non-hip—occurring post randomisation. Fall-related hospital presentations are a secondary outcome.

Discussion: This substudy will determine whether a widely available, simple and inexpensive health intervention—aspirin—reduces the risk of fractures in older Australians. If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.

Trial registration number: The protocol for this substudy is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615000347561).

Year2016
JournalInjury Prevention
Journal citation22 (4), pp. 297-301
PublisherBMJ Publishing Group
ISSN1353-8047
Digital Object Identifier (DOI)https://doi.org/10.1136/injuryprev-2015-041655
PubMed ID26002770
Scopus EID2-s2.0-84931473213
PubMed Central IDPMC4879092
Open accessPublished as green open access
Page range297-301
FunderNational Health and Medical Research Council (NHMRC)
Research GroupInstitute for Health and Ageing
Author's accepted manuscript
License
File Access Level
Open
Publisher's version
File Access Level
Controlled
Output statusPublished
Publication dates
Online21 May 2015
Publication process dates
Accepted21 Apr 2015
Grant ID1067242
1067236
Permalink -

https://acuresearchbank.acu.edu.au/item/891zw/a-randomised-controlled-trial-of-low-dose-aspirin-for-the-prevention-of-fractures-in-healthy-older-people-protocol-for-the-aspree-fracture-substudy

Log in to edit

Download files

Author's accepted manuscript
AM_Barker_2016_A_randomised_controlled_trial_of_low-dose.pdf
License: CC BY-NC 4.0
File access level: Open

Restricted files

Publisher's version

  • 92
    total views
  • 26
    total downloads
  • 2
    views this month
  • 2
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis
Ghasem-Zadeh, Ali, Bui, Minh, Seeman, Ego, Boyd, Steven K., Iuliano, Sandra, Jaipurwala, Rizwan, Mount, Peter F., Toussaint, Nigel D. and Chiang, Cherie. (2022). Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis. Bone. 154, p. Article 116260. https://doi.org/10.1016/j.bone.2021.116260
The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study
Hu, Yizhong, Chines, Arkadi, Shi, Yifei, Seeman, Ego and Guo, X. Edward. (2022). The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study. Bone. 154, p. 116187. https://doi.org/10.1016/j.bone.2021.116187
Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)
Talevski, J, Sanders, K. M., Watts, J. J., Nicholson, G. C., Seeman, E., Iuliano, S., Prince, R., March, L., Winzenberg, T., Duque, G., Ebeling, P. R., Borgström, F., Kanis, J. A., Stuart, A. L., Beauchamp, A. and Brennan-Olsen, S. L.. (2022). Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 33(1), pp. 67-75. https://doi.org/10.1007/s00198-021-06058-3
Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia
Warren, Annabelle M., Ebeling, Peter R., Grill, Vivian, Seeman, Ego and Sztal-Mazer, Shoshana. (2021). Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia. Endocrinology, Diabetes & Metabolism. 2021(1), pp. 1-5. https://doi.org/10.1530/EDM-21-0096
Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R
Martin, T. John, Sims, Natalie A. and Seeman, Ego. (2021). Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R. Endocrine Reviews. 42(4), pp. 383-406. https://doi.org/10.1210/endrev/bnab005
Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)
Talevski, Jason, Sanders, Kerrie M., Vogrin, Sara, Duque, Gustavo, Beauchamp, Alison, Seeman, Ego, Iuliano, Sandra, Svedbom, Axel, Borgström, Fredrik, Kanis, John A., Stuart, Amanda L. and Brennan-Olsen, Sharon L.. (2021). Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Archives of Osteoporosis. 16, p. Article 112. https://doi.org/10.1007/s11657-021-00981-y
Heterogeneity in microstructural deterioration following spinal cord injury
Ghasem-Zadeh, Ali, Galea, Mary P., Nunn, Andrew, Panisset, Maya, Wang, Xiao-Fang, Iuliano, Sandra, Boyd, Steven K., Forwood, Mark R. and Seeman, Ego. (2021). Heterogeneity in microstructural deterioration following spinal cord injury. Bone. 142, p. 115778. https://doi.org/10.1016/j.bone.2020.115778
High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures
Zendeli, Afrodite, Bui, Minh, Fischer, Lukas, Ghasem-Zadeh, Ali, Schima, Wolfgang and Seeman, Ego. (2021). High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures. Journal of Clinical Sleep Medicine. 10(5), pp. 1-10. https://doi.org/10.3390/jcm10051123
Health service use pathways associated with recovery of quality of life at 12-months for individual fracture sites : Analyses of the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS)
Talevski, Jason, Sanders, Kerrie M., Busija, Ljoudmila, Beauchamp, Alison, Duque, Gustavo, Borgström, Fredrik, Kanis, John A., Svedbom, Axel, Stuart, Amanda L. and Brennan-Olsen, Sharon. (2021). Health service use pathways associated with recovery of quality of life at 12-months for individual fracture sites : Analyses of the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS). Bone. 114, p. 115805. https://doi.org/10.1016/j.bone.2020.115805
Health service use and quality of life recovery 12 months following major osteoporotic fracture : latent class analyses of the international costs and utilities related to osteoporotic fractures study (ICUROS)
Talevski, Jason, Sanders, Kerrie M., Busija, Ljoudmila, Beauchamp, Alison, Duque, Gustavo, Borgström, Fredrik, Kanis, John A., Svedbom, Axel, Connaughton, Catherine, Stuart, Amanda L. and Brennan-Olsen, Sharon L.. (2021). Health service use and quality of life recovery 12 months following major osteoporotic fracture : latent class analyses of the international costs and utilities related to osteoporotic fractures study (ICUROS). Journal of Bone and Mineral Research. 36(2), pp. 252-261. https://doi.org/10.1002/jbmr.4181
Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration
Liew, Danny, Chapurlat, R. D., Sornay-Rendu, E., Lespessailles, Eric, Peng, Yu and Seeman, Ego. (2021). Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration. Bone. 142, p. 115682. https://doi.org/10.1016/j.bone.2020.115682
Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy
Ramchand, Sabashini and Seeman, Ego. (2020). Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy. In In Stern, Paula H. (Ed.). Bone regulators and osteoporosis therapy pp. 423-450 Springer Nature Switzerland AG. https://doi.org/10.1007/164_2020_354
The role of elders in the wellbeing of a contemporary Australian Indigenous community
Busija, Lucy, Cinelli, Renata, Toombs, Maree R., Easton, Caitlin, Hampton, Ron, Holdsworth, Kristen, Macleod, Ashley, Nicholson, Geoffrey C., Nasir, Bushra F., Sanders, Kerrie M. and McCabe, Marita P.. (2020). The role of elders in the wellbeing of a contemporary Australian Indigenous community. Gerontologist. 60(3), pp. 513-524. https://doi.org/10.1093/geront/gny140
Consumer directed care in residential aged care : An evaluation of a staff training program
McCabe, Marita P., Beattie, Elizabeth, Karantzas, Gery, Mellor, David, Sanders, Kerrie, Busija, Lucy, Goodenough, Belinda, Bennett, Michelle, von Treuer, Kathryn and Byers, Jessica. (2020). Consumer directed care in residential aged care : An evaluation of a staff training program. Aging and Mental Health. 24(4), pp. 673-678. https://doi.org/10.1080/13607863.2019.1574711
Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial
Cheung, Ada S., Hoermann, Rudolf, Ghasem-Zadeh, Ali, Tinson, Alistair J., Ly, Vivian, Milevski, Stefan V., Joon, Daryl Lim, Zajac, Jeffrey D., Seeman, Ego and Grossmann, Mathis. (2020). Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial. Journal of Bone and Mineral Research. 35(10), pp. 1871-1880. https://doi.org/10.1002/jbmr.4106
Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study
Chapurlat, Roland, Bui, Minh, Sornay-Rendu, Elisabeth, Zebaze, Roger, Delmas, Pierre D., Liew, Danny, Lespessailles, Eric and Seeman, Ego. (2020). Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study. Journal of Bone and Mineral Research. 35(6), pp. 833-844. https://doi.org/10.1002/jbmr.3924
Osteocalcin and its forms across the lifespan in adult men
Smith, Cassandra, Voisin, Sarah, Al Saedi, Ahmed, Phu, Steven, Brennan-Speranza, Tara C., Parker, Lewan, Eynon, Nir, Hiam, Danielle S., Yan, Xu, Scott, David, Blekkenhorst, Lauren C., Lewis, Joshua R., Seeman, Ego, Byrnes, Elizabeth, Flicker, Leon, Duque, Gustavo, Yeap, Bu B. and Levinger, Itamar. (2020). Osteocalcin and its forms across the lifespan in adult men. Bone. 130, pp. 1 - 6. https://doi.org/10.1016/j.bone.2019.115085
Resident perceptions of opportunity for communication and contribution
Bennett, Michelle, Treuer, Kathryn von, McCabe, Marita P., Beattie, Elizabeth, Karantzas, Gery, Mellor, David, Sanders, Kerrie, Busija, Ljoudmila, Goodenough, Belinda and Byers, Jessica. (2020). Resident perceptions of opportunity for communication and contribution. International Journal of Older People Nursing. 15(1), pp. 1 - 11. https://doi.org/10.1111/opn.12276
Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy
Seeman, Ego. (2019). Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy. In In Bilezikian, John P., Martin, T. John, Clemens, Thomas L. and Rosen, Clifford J. (Ed.). Principles of bone biology ; volume 1 pp. 245-274 Academic Press. https://doi.org/10.1016/B978-0-12-814841-9.00011-7
The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017
Tatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M.. (2019). The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. Journal of Bone and Mineral Research. 34(4), pp. 616 - 625. https://doi.org/10.1002/jbmr.3640
Skeletal growth: A major determinant of bone's structural diversity in women and men
Seeman, Ego. (2019). Skeletal growth: A major determinant of bone's structural diversity in women and men. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 123 - 130 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch16
Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults
Liu, Yusi, Poon, Shirley, Seeman, Ego, Hare, David L., Bui, Minh Q. and Iuliano, Sandra. (2019). Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults. Journal of Nutritional Science. 8(e10), pp. 1 - 8. https://doi.org/10.1017/jns.2019.5
Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women
Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zhou, Bin, Guo, X. Edward, Zhang, Zhendong and Seeman, Ego. (2019). Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women. Bone. 128, pp. 1 - 7. https://doi.org/10.1016/j.bone.2019.115039
Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis
Talevski, Jason, Sanders, Kerrie M., Duque, Gustavo, Connaughton, Catherine, Beauchamp, Alison, Green, Darci, Millar, Lynne and Brennan-Olsen, Sharon L.. (2019). Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis. Journal of the American Medical Directors Association. 20(7), pp. 926.e1 - 926.e11. https://doi.org/10.1016/j.jamda.2019.02.022
Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls
Zebaze, Roger M., Osima, Marit, Bui, Minh Q., Lukic, Marko, Wang, Xiaofang, Ghasem-Zadeh, Ali, Eriksen, Erik F., Vais, Angela, Shore-Lorenti, Catherine, Ebeling, Peter R., Seeman, Ego and Bjørnerem, Ashild. (2019). Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls. Journal of Bone and Mineral Research. 34(8), pp. 1451 - 1460. https://doi.org/10.1002/jbmr.3721
Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration
Zebaze, Roger M., Atkinson, Elizabeth J., Peng, Yu, Bui, Minh, Ghasem-Zadeh, Ali, Khosla, Sundeep and Seeman, Ego. (2019). Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration. JBMR Plus. 3(4), pp. 1 - 7. https://doi.org/10.1002/jbm4.10078
Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin
Parker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin. Journal of Bone and Mineral Research. 34(1), pp. 49-58. https://doi.org/10.1002/jbmr.3574
Do replicable profiles of multimorbidity exist? Systematic review and synthesis
Busija, Ljoudmila, Lim, Karen, Szoeke, Cassandra, Sanders, Kerrie M. and McCabe, Marita P.. (2019). Do replicable profiles of multimorbidity exist? Systematic review and synthesis. European Journal of Epidemiology. 34, pp. 1025 - 1053. https://doi.org/10.1007/s10654-019-00568-5
Menopause and age-related bone loss
Isales, Carlos M. and Seeman, Ego. (2019). Menopause and age-related bone loss. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 155 - 161 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch21
Antiresorptive and anabolic agents in the prevention and reversal of bone fragility
Seeman, Ego and Martin, T. J.. (2019). Antiresorptive and anabolic agents in the prevention and reversal of bone fragility. Nature Reviews Rheumatology. 15(4), pp. 225 - 236. https://doi.org/10.1038/s41584-019-0172-3
A randomized controlled trial to evaluate the effectiveness of a staff training program to implement consumer directed care on resident quality of life in residential aged care
Marita McCabe, Elizabeth Beattie, Gery Karantzas, David Mellor, Kerrie Sanders, Lucy Busija, Belinda Goodenough, Michelle Bennett, Kathryn von Treuer and Jessica Byers. (2018). A randomized controlled trial to evaluate the effectiveness of a staff training program to implement consumer directed care on resident quality of life in residential aged care. BMC Geriatrics. 18(1), pp. 1-8. https://doi.org/10.1186/s12877-018-0966-1
Stepping strategy used to recover balance during an induced fall is associated with impaired function and strength in people with knee osteoarthritis
Levinger, P., Downie, Calum, Nagano, Hanatsu, Petersen, Aaron, Hayes, A., Sanders, Kerrie, Cicuttini, Flavia and Begg, Rezaul. (2018). Stepping strategy used to recover balance during an induced fall is associated with impaired function and strength in people with knee osteoarthritis. International Journal of Rheumatic Diseases. 21(10), pp. 1763 - 1771. https://doi.org/10.1111/1756-185X.12891
Calf muscle density in independently associated with physical function in overweight and obese older adults
Scott, David, Shore-Lorenti, Catherine, McMillan, L. B., Mesinovic, J., Clark, Ross, Hayes, A., Sanders, Kerrie, Duque, Gustavo and Ebeling, Peter. (2018). Calf muscle density in independently associated with physical function in overweight and obese older adults. The Journal of Musculoskeletal and Neuronal Interactions. 18(1), pp. 9 - 17.
The influence of cortical porosity on the strength of bone during growth and advancing age
Ramchand, S. K. and Seeman, Ego. (2018). The influence of cortical porosity on the strength of bone during growth and advancing age. Current Osteoporosis Reports. 16(5), pp. 561 - 572. https://doi.org/10.1007/s11914-018-0478-0
Mechanical loading of the femoral neck in human locomotion
Kersh, M. E., Martelli, Saulo, Zebaze, Roger M., Seeman, Ego and Pandy, Marcus. (2018). Mechanical loading of the femoral neck in human locomotion. Journal of Bone and Mineral Research. 33(11), pp. 1999 - 2006. https://doi.org/10.1002/jbmr.3529
Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children
Cheuk, Ka Yee, Wang, Xiao-Fang, Wang, Ji, Zhang, Zhendong, Yu, Fiona Wai Ping, Tam, Elisa Man Shan, Hung, Vivian Wing Yin, Lee, Wayne Yuk Wai, Ghasem-Zadeh, Ali, Zebaze, Roger, Zhu, Tracy Y., Guo, X. Edward, Cheng, Jack Chun Yiu, Lam, Tsz Ping and Seeman, Ego. (2018). Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children. Journal of Bone and Mineral Research. 33(11), pp. 1948 - 1955. https://doi.org/10.1002/jbmr.3551
Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets
Chiang, Cherie Y., Zebaze, Roger, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zajac, Jeffrey D. and Seeman, Ego. (2018). Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets. Journal of Bone and Mineral Research. 33(7), pp. 1312 - 1317. https://doi.org/10.1002/jbmr.3415
Systemic mastocytosis identified in two women developing fragility fractures during lactation
Zhu, J. J., Mahendran, D., Lee, M.H., Seah, J., Fourlanos, S., Varadarajan, S., Ghasem-Zadeh, Ali, MacIsaac, Richard and Seeman, Ego. (2018). Systemic mastocytosis identified in two women developing fragility fractures during lactation. Osteoporosis International. 29(7), pp. 1671 - 1674. https://doi.org/10.1007/s00198-018-4498-5
The material and structural basis of the growth-related gain and age-related loss of bone strength
Seeman, Ego. (2018). The material and structural basis of the growth-related gain and age-related loss of bone strength. In In N. C. Harvey and C. Cooper (Ed.). Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health pp. 105 - 122 CRC Press. https://doi.org/10.1201/9781351234627-9
An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly
Tieland, Michael, Beelen, Janne, Laan, Anna C. M., Poon, Shirley, de Groot, Lisette C. P. G. M., Seeman, Ego, Wang, Xiaofang and Iuliano, Sandra. (2018). An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 19(1), pp. 33 - 39. https://doi.org/10.1016/j.jamda.2017.07.007
Associations of components of sarcopenic obesity with bone health and balance in older adults
Scott, David, Shore-Lorenti, Catherine, McMillan, Lachlan, Mesinovic, Jakub, Clark, Ross, Hayes, A., Sanders, Kerrie, Duque, Gustavo and Ebeling, Peter. (2018). Associations of components of sarcopenic obesity with bone health and balance in older adults. Archives of Gerontology and Geriatrics. 75, pp. 125 - 131. https://doi.org/10.1016/j.archger.2017.12.006
The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study
Leslie, William D., Seeman, Ego, Morin, Suzanne N., Lix, Lisa and Majumdar, S. R.. (2018). The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study. Bone. 114, pp. 298 - 303. https://doi.org/10.1016/j.bone.2018.07.004
Characteristics of recurrent fractures
Kanis, J. A., Johansson, H., Odén, A., Harvey, N. C., Gudnason, V., Sanders, K., Sigurdsson, G., Siggeirsdottir, K., Fitzpatrick, L. A., Borgström, F. and McCloskey, E. V.. (2018). Characteristics of recurrent fractures. Osteoporosis International. 29(8), pp. 1747-1757. https://doi.org/10.1007/s00198-018-4502-0
Advances and unmet needs in the therapeutics of bone fragility
Ramchand, S. K. and Seeman, Ego. (2018). Advances and unmet needs in the therapeutics of bone fragility. Frontiers in Endocrinology. 9, pp. 1 - 10. https://doi.org/10.3389/fendo.2018.00505
Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity
Bjørnerem, Ashild, Wang, Xiaofang, Bui, Q. M., Ghasem-Zadeh, Ali, Hopper, John, Zebaze, Roger M. and Seeman, Ego. (2018). Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity. Journal of Bone and Mineral Research. 33(4), pp. 598 - 605. https://doi.org/10.1002/jbmr.3333
Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide
Zebaze, Roger, Takao-Kawabata, Ryoko, Peng, Yu, Zadeh, Ali Ghasem, Hirano, Kyoko, Yamane, Hiroshi, Takakura, Aya, Isogai, Yukihiro, Ishizuya, Toshinori and Seeman, Ego. (2017). Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide. Bone. 99, pp. 80 - 84. https://doi.org/10.1016/j.bone.2017.03.042
Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults
Shang, Xianwen, Scott, David, Hodge, Allison, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie. (2017). Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults. Clinical Nutrition. 36(6), pp. 1540 - 1548. https://doi.org/10.1016/j.clnu.2016.09.024
Dairy food supplementation may reduce malnutrition risk in institutionalised elderly
Iuliano, Sandra, Poon, Shirley, Wang, Xiaofang, Bui, Minh and Seeman, Ego. (2017). Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. British Journal of Nutrition. 117(1), pp. 142 - 147. https://doi.org/10.1017/S000711451600461X
Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury
Sanders, Kerrie, Lim, Karen, Stuart, Amanda L., Macleod, Ashley, Scott, David, Nicholson, Geoff and Busija, Lucy. (2017). Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury. Osteoporosis International. 28(10), pp. 3005 - 3015. https://doi.org/10.1007/s00198-017-4145-6
Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease
Seeman, Ego. (2017). Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease. Nephrology. 22(Suppl 2), pp. 34 - 35. https://doi.org/10.1111/nep.13024
Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS
Svedbom, A., Borgström, Fredrik, Hernlund, E., Ström, O., Alekna, V., Bianchi, Maria L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Uusküla, A., Lember, M., Kallikorm, R., Lesnyak, Olga, McCloskey, Eugene, Ershova, Olga, Sanders, Kerrie, Silverman, S., Tamulaitiene, M., ... Kanis, John. (2017). Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS. Quality of Life Research. 27(3), pp. 707 - 716. https://doi.org/10.1007/s11136-017-1748-5
Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Serum 25-hydroxyvitamin d insufficiency in search of a bone disease
Shah, Sonali, Chiang, Cherie, Sikaris, Ken, Lu, Zhong, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Serum 25-hydroxyvitamin d insufficiency in search of a bone disease. The Journal of Clinical Endocrinology and Metabolism. 102(7), pp. 2321 - 2328. https://doi.org/10.1210/jc.2016-3189
Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding
Bjørnerem, Åshild, Ghasem-Zadeh, Ali, Wang, Xiaofang, Bui, Minh, Walker, Susan P., Zebaze, Roger and Seeman, Ego. (2017). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research. 32(4), pp. 681 - 687. https://doi.org/10.1002/jbmr.3018
Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS
Svedbom, A., Borgstöm, F., Hernlund, E., Ström, O., Alekna, V., Bianchi, M. L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Kallikorm, R., Lember, M., Lesnyak, Olga, McCloskey, Eugene, Sanders, Kerrie, Silverman, S., Solodovnikov, A., Tamulaitiene, M., Thomas, T., ... John, Handelshogskolan i Stockholm. (2017). Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS. Osteoporosis International. 29(3), pp. 557 - 566. https://doi.org/10.1007/s00198-017-4317-4
Vitamin D, bones and muscle: myth versus reality
Duque, Gustavo, Daly, Rob, Sanders, Kerrie and Kiel, Douglas P.. (2017). Vitamin D, bones and muscle: myth versus reality. Australasian Journal on Ageing. 36(1), pp. 8 - 13. https://doi.org/10.1111/ajag.12408
Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey
Busija, Lucy, Tan, Jeretine and Sanders, Kerrie. (2017). Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey. Quality of Life Research. 26(10), pp. 2671 - 2681. https://doi.org/10.1007/s11136-017-1592-7
The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study
Levinger, P., Begg, Rezaul, Sanders, Kerrie, Nagano, Hanatsu, Downie, Calum, Petersen, Aaron, Hayes, A. and Cicuttini, Flavia. (2017). The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study. Archives of Osteoporosis. 12(83), pp. 1 - 6. https://doi.org/10.1007/s11657-017-0378-4
Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure
Ramchand, Sabashini K., Seeman, Ego, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Francis, Prudence A., Ponnusamy, Evangeline J., Bardin, Michele S., Bui, Minh, Zebaze, Roger, Zajac, Jeffrey D. and Grossmann, Mathis. (2017). Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. Bone. 103, pp. 131 - 135. https://doi.org/10.1016/j.bone.2017.06.024
Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults
Shang, Xianwen, Scott, David, Hodge, Allison, Khan, Belal, Khan, Nayab, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie. (2017). Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults. Journal of Nutrition, Health and Aging. 21(2), pp. 147 - 151. https://doi.org/10.1007/s12603-016-0738-6
Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions
Ghasem-Zadeh, Ali, Burghardt, Andrew, Wang, Xiao-Fang, Iuliano, Sandra, Bonaretti, Serena, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 101, pp. 206 - 213. https://doi.org/10.1016/j.bone.2017.05.010
Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Abaloparatide is an anabolic, but does it spare resorption?
Martin, T. John and Seeman, Ego. (2017). Abaloparatide is an anabolic, but does it spare resorption? Journal of Bone and Mineral Research. 32(1), pp. 11 - 16. https://doi.org/10.1001/jama.2016.11136
Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age
Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age. Journal of Clinical Densitometry. 20(1), pp. 5 - 7. https://doi.org/10.1016/j.jocd.2016.08.006
A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol
Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119
Glucose-loading reduces bone remodeling in women and osteoblast function in vitro
Levinger, Itamar, Seeman, Ego, Jerums, George, McConell, Glenn K., Rybchyn, Mark S., Cassar, Samantha, Byrnes, Elizabeth, Selig, Steve, Mason, Rebecca S., Ebeling, Peter R. and Brennan-Speranza, Tara C.. (2016). Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiological Reports. 4(3), pp. 1 - 10. https://doi.org/10.14814/phy2.12700
Non-hip and non-vertebral fractures: the neglected fracture sites
Holloway, Kara, Henry, Margaret, Brennan-Olsen, Sharon, Bucki-Smith, Gosia, Nicholson, Geoffrey Charles, Korn, S., Sanders, Kerrie, Pasco, Julie and Kotowicz, Mark. (2016). Non-hip and non-vertebral fractures: the neglected fracture sites. Osteoporosis International. 27(3), pp. 905 - 913. https://doi.org/10.1007/s00198-015-3322-8
Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report
Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego. (2016). Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report. Osteoporosis International. 27(2), pp. 821 - 825. https://doi.org/10.1007/s00198-015-3354-0
The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Levinger, Itamar, Lin, X, Zhang, X., Brennan-Speranza, T C., Volpato, B, Hayes, A., Jeru, G, Seeman, Ego and Mcconell, Glenn K.. (2016). The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporosis International. 27(2), pp. 653 - 663. https://doi.org/10.1007/s00198-015-3273-0
The association between anxiety and falls: A meta-analysis
Hallford, David John, Nicholson, Geoffrey Charles, Sanders, Kerrie and McCabe, Marita Patricia. (2016). The association between anxiety and falls: A meta-analysis. Journal of Gerontology: Psychological Sciences. 00(00), pp. 1 - 13. https://doi.org/10.1093/geronb/gbv160
Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better
Sanders, Kerrie and Seibel, Markus J.. (2016). Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better. Nature Reviews Endocrinology. 12(4), pp. 190 - 191. https://doi.org/10.1038/nrendo.2016.29
Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data
Brennan-Olsen, Sharon L., Page, Richard S., Lane, Steven E., Lorimer, Michelle, Buchbinder, Rachelle, Osborne, Richard H., Pasco, Julie A., Wluka, Anita E., Sanders, Kerrie M., Ebeling, Peter R. and Graves, Stephen E.. (2016). Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data. BMC Musculoskeletal Disorders. 17(291), pp. 1 - 9. https://doi.org/10.1186/s12891-016-1134-4
Challenges in the acquisition and analysis of bone microstructure during growth
Seeman, Ego and Ghasem-Zadeh, Ali. (2016). Challenges in the acquisition and analysis of bone microstructure during growth. Journal of Bone and Mineral Research. 31(12), pp. 2239 - 2241. https://doi.org/10.1002/jbmr.3015
Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies
Shang, Xianwen, Scott, David, Hodge, Allison M., English, Dallas R., Giles, Graham G., Ebeling, Peter R. and Sanders, Kerrie M.. (2016). Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies. American Journal of Clinical Nutrition. 104(5), pp. 1352 - 1365. https://doi.org/10.3945/ajcn.116.140954
Bone remodeling markers: So easy to measure, so difficult to interpret
Seeman, E. and Nguyen, T. V.. (2016). Bone remodeling markers: So easy to measure, so difficult to interpret. Osteoporosis International. 27, pp. 33 - 35. https://doi.org/10.1007/s00198-015-3374-9
Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis
Zebaze, Roger M., Libanati, Cesar, McClung, Michael R., Zanchetta, Jose Ruben, Kendler, David L., Høiseth, Arne, Wang, Andrea, Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research. 31(10), pp. 1827 - 1834. https://doi.org/10.1002/jbmr.2855
Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults
Scott, David, Ebeling, Peter, Sanders, Kerrie, Aitken, Dawn, Winzenberg, Tania and Jones, Graeme. (2015). Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults. The Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 670 - 678. https://doi.org/10.1210/jc.2014-3519
Osteoporosis: Treat or let die twice more likely
Nguyen, Tuan V. and Seeman, Ego. (2015). Osteoporosis: Treat or let die twice more likely. Journal of Bone and Mineral Research. 30(9), pp. 1551 - 1552. https://doi.org/10.1002/jbmr.2601/pdf
Cortical bone: A challenging geography
Zebaze, Roger and Seeman, Ego. (2015). Cortical bone: A challenging geography. Journal of Bone and Mineral Research. 30(1), pp. 24 - 29. https://doi.org/10.1002/jbmr.2419
Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft
Perilli, Egon, Bala, Yohann, Zebaze, Roger M., Reynolds, Karen J. and Seeman, Ego. (2015). Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcified Tissue International. 97(4), pp. 327 - 335. https://doi.org/10.1007/s00223-015-0014-5
Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial
Sanders, Kerrie M., Stuart, Amanda L., Scott, David, Kotowicz, Mark A. and Nicholson, Geoff C.. (2015). Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial. International Journal of Endocrinology. https://doi.org/10.1155/2015/210527
Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)
Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015). Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z
Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial
Daly, Robin, Duckham, Rachel, Tait, Jamie, Rantalainen, Timo, Nowson, Caryl, Taaffe, Dennis, Sanders, Kerrie, Hill, Keith, Kidgell, Dawson and Busija, Ljoudmila. (2015). Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial. Trials (online). 16(120), pp. 1 - 15. https://doi.org/10.1186/s13063-015-0652-y
Humeral fractures in south-eastern Australia: Epidemiology and risk factors
Holloway, Kara, Bucki-Smith, Gosia, Morse, Amelia, Brennan-Olsen, Sharon, Kotowicz, Mark, Moloney, David, Sanders, Kerrie, Korn, S, Timney, Elizabeth, Dobbins, Amelia and Pasco, Julie. (2015). Humeral fractures in south-eastern Australia: Epidemiology and risk factors. Calcified Tissue International. 97(5), pp. 453 - 465. https://doi.org/10.1007/s00223-015-0039-9
Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study
Bjornerem, Ashild, Bui, Q Minh, Wang, Xiaofang, Ghasem-Zadeh, Ali, Hopper, John L., Zebaze, Roger M. and Seeman, Ego. (2015). Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study. Journal of Bone and Mineral Research. 30(3), pp. 516 - 524. https://doi.org/10.1002/jbmr.2365
Bones material constituents and their contribution to bone strength in health, disease, and treatment
Bala, Y. and Seeman, Ego. (2015). Bones material constituents and their contribution to bone strength in health, disease, and treatment. Calcified Tissue International. 97(3), pp. 308 - 326. https://doi.org/10.1007/s00223-015-9971-y
A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015
Manolagas, Stavros C., Compston, Juliet, Rao, Sudhaker and Seeman, Ego. (2015). A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015. Journal of Bone and Mineral Research. 30(8), pp. 1349 - 1355. https://doi.org/10.1002/jbmr.2576
Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men
Shang, Xianwen, Sanders, Kerrie, Scott, David, Khan, Belal, Hodge, Allison, Khan, Nayab, English, Dallas, Giles, Graham and Ebeling, Peter. (2015). Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men. The Journal of Nutrition. 145(8), pp. 1778 - 1786. https://doi.org/10.3945/jn.115.211789
Co-administration of antiresorptive and anabolic agents: A missed opportunity
Seeman, Ego and Martin, T. John. (2015). Co-administration of antiresorptive and anabolic agents: A missed opportunity. Journal of Bone and Mineral Research. 30(5), pp. 753 - 764. https://doi.org/10.1002/jbmr.2496
Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture
Scott, David, McLaughlin, Patrick, Nicholson, Geoff C., Ebeling, Peter, Stuart, Amanda, Kay, Deborah and Sanders, Kerrie. (2015). Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture. Age and Ageing. 44(2), pp. 287 - 293. https://doi.org/10.1093/ageing/afu169
The ABC of writing a grant proposal
Seeman, Ego. (2015). The ABC of writing a grant proposal. Osteoporosis International. 26(6), pp. 1665 - 1666. https://doi.org/10.1007/s00198-015-3085-2
Growth and age-related abnormalities in cortical structure and fracture risk
Seeman, Ego. (2015). Growth and age-related abnormalities in cortical structure and fracture risk. Endocrinology and Metabolism. 30(4), pp. 419 - 428. https://doi.org/10.3803/EnM.2015.30.4.419
Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial
Gianoudis, Jenny, Bailey, Christine A., Ebeling, Peter R., Nowson, Caryl A., Sanders, Kerrie M., Hill, Keith and Daly, Robin M.. (2014). Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial. Journal of Bone and Mineral Research. 29(1), pp. 182 - 191. https://doi.org/10.1002/jbmr.2014
Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Lane, Stephen E., Lorimer, Michelle, Buchbinder, Rachelle, Wluka, Anita E., Page, Richard S., Osborne, Richard H., Pasco, Julie A., Sanders, Kerrie M., Cashman, Kara, Ebeling, Peter R. and Graves, Stephen E.. (2014). Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 15(356), pp. 1 - 9. https://doi.org/10.1186/1471-2474-15-356
Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults
Scott, David, Sanders, Kerrie M., Aitken, Dawn, Hayes, Alan, Ebeling, Peter R. and Jones, Graeme. (2014). Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults. Obesity. 22(6), pp. 1568 - 1574. https://doi.org/10.1002/oby.20734
Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study
Simpson, Richard W., Nicholson, Geoffrey C., Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M., Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy and Wacher, Vincent J.. (2014). Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study. Diabetes Care. 37(11), pp. 3121 - 3123. https://doi.org/10.2337/dc14-1038
Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes
Shore-Lorenti, Catherine, Brennan, Sharon L., Sanders, Kerrie M., Neale, Rachel E., Lucas, Robyn M. and Ebeling, Peter R.. (2014). Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes. Clinical Endocrinology. 81(6), pp. 799 - 811. https://doi.org/10.1111/cen.12567
Serum selenium status in Graves' disease with and without orbitopathy: A case-control study
Khong, Jwu Jin, Goldstein, Rebecca F., Sanders, Kerrie M., Schneider, Hans, Pope, Jeffrey, Burdon, Kathryn P., Craigh, Jamie E., Ebeling, Peter R. and Peter, . (2014). Serum selenium status in Graves' disease with and without orbitopathy: A case-control study. Clinical Endocrinology. 80(6), pp. 905 - 910. https://doi.org/10.1111/cen.12392
Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture
Scott, David, Stuart, Amanda, Kay, Deborah, Ebeling, Peter, Nicholson, Geoffrey and Sanders, Kerrie. (2014). Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture. Archives of Gerontology and Geriatrics. 58(3), pp. 308 - 313. https://doi.org/10.1016/j.archger.2013.11.004
The prevalence of vitamin B12 deficiency in a random sample from the Australian population
Moore, Eileen, Pasco, Julie, Mander, Alastair, Sanders, Kerrie, Carne, Ross, Jenkins, Nicole, Black, Marion, Schneider, Hans, Ames, David and Watters, David. (2014). The prevalence of vitamin B12 deficiency in a random sample from the Australian population. Journal of Investigational Biochemistry. 3(3), pp. 95 - 100. https://doi.org/10.5455/jib.20140716041521
Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Levinger, Itamar, Scott, David, Nicholson, Geoffrey, Stuart, Amanda, Duque, Gustavo, McCorquodale, Thomas, Herrmann, Markus, Ebeling, Peter and Sanders, Kerrie. (2014). Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 64, pp. 8 - 12. https://doi.org/10.1016/j.bone.2014.03.008
High-resolution in vivo imaging of bone and joints: a window to microarchitecture
Geusens, P., Geusens, P., Chapurlat, Roland D., Chapurlat, Roland D., Schett, G., Ghasem-Zadeh, Ali, Ghasem-Zadeh, Ali, Seeman, Ego, De Jong, J. and Van Den Bergh, J.. (2014). High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nature Reviews Rheumatology. 10(5), pp. 304 - 313. https://doi.org/10.1038/nrrheum.2014.23
A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images
Zebaze, Roger M., Ghasem-Zadeh, Ali, Mbala, A. and Seeman, Ego. (2013). A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 54(1), pp. 8 - 20. https://doi.org/10.1016/j.bone.2013.01.007
Is high dose Vitamin D harmful?
Sanders, Kerrie, Nicholson, Geoffrey and Ebeling, Peter. (2013). Is high dose Vitamin D harmful? Calcified Tissue International. 92(2), pp. 191 - 206. https://doi.org/10.1007/s00223-012-9679-1
Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy
Chiang, Cherie Ying, Zebaze, Roger M.D., Ghasem-Zadeh, Ali, Iuliano-Burns, Sandra, Hardidge, Andrew and Seeman, Ego. (2013). Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 52(1), pp. 360 - 365. https://doi.org/10.1016/j.bone.2012.10.006
Vitamin D and health in adults in Australia and New Zealand : A position statement
Nowson, Caryl A., McGrath, John J., Ebeling, Peter R., Haikerwal, Anjali, Daly, Robin M., Sanders, Kerrie M., Seibel, Markus J. and Mason, Rebecca S.. (2012). Vitamin D and health in adults in Australia and New Zealand : A position statement. Medical Journal of Australia. 196(11), pp. 686-687. https://doi.org/10.5694/mja11.10301
Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures
Gianoudis, Jenny, Bailey, Christine A., Sanders, Kerrie M., Nowson, Caryl A., Hill, Keith, Ebeling, Peter R. and Daly, Robin M.. (2012). Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures. BMC Musculoskeletal Disorders. 13(78), pp. 1 - 16. https://doi.org/10.1186/1471-2474-13-78
Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial
Wustrack, R., Seeman, Ego, Bucci-Rechtweg, C. and Burch, S.. (2012). Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial. Osteoporosis International. 23(1), pp. 53 - 58. https://doi.org/10.1007/s00198-011-1664-4
Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials
Rejnmark, Lars, Avenell, Alison, Masud, Tahir, Anderson, Frazer, Meyer, Haakon E., Sanders, Kerrie M., Salovaara, Kari, Cooper, Cyrus, Smith, Helen E., Jacobs, Elizabeth T., Torgerson, David, Jackson, Rebecca D., Manson, JoAnn E., Brixon, Kim, Mosekilde, Leif, Robbins, John A., Francis, Roger M. and Abrahamsen, Bo. (2012). Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials. The Journal of Clinical Endocrinology and Metabolism. 97(8), pp. 2670 - 2681. https://doi.org/10.1210/jc.2011-3328
Fracture risk score and absolute risk of fracture
Henry, Margaret, Pasco, Julie, Merriman, Elizabeth, Zhang, Yu, Sanders, Kerrie, Kotowicz, Mark and Nicholson, Geoffrey. (2011). Fracture risk score and absolute risk of fracture. Radiology. 259(2), pp. 495 - 501. https://doi.org/10.1148/radiol.10101406
Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007
Pasco, Julie, Brennan, Sharon, Henry, Margaret, Nicholson, Geoffrey, Sanders, Kerrie, Zhang, Yu and Kotowicz, Mark. (2011). Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26(7), pp. 1648 - 1654. https://doi.org/10.1002/jbmr.393
The effect of acute exercise on undercarboxylated osteocalcin in obese men
Levinger, Itamar, Zebaze, Roger M., Jeru, G., Hare, David L., Selig, Steve and Seeman, Ego. (2011). The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International. 22(5), pp. 1621 - 1626. https://doi.org/10.1007/s00198-010-1370-7
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial
Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie, Nicholson, Geoffrey, Seibel, Markus, Salmon, Jo and Daly, Robin. (2011). Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial. The Journal of Clinical Endocrinology and Metabolism. 96(4), pp. 955 - 963. https://doi.org/10.1210/jc.2010-2284
Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial
Peake, Jonathan, Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie and Daly, Robin. (2011). Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial. European Journal of Applied Physiology. 111(12), pp. 3079 - 3088. https://doi.org/10.1007/s00421-011-1942-z
Paracetamol (acetaminophen) use, fracture and bone mineral density
Williams, Lana, Pasco, Julie, Henry, Margaret, Sanders, Kerrie, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael. (2011). Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 48(6), pp. 1277 - 1281. https://doi.org/10.1016/j.bone.2011.03.435
Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial
Sanders, Kerrie, Stuart, Amanda, Williamson, Elizabeth, Jacka, Felice, Dodd, Seetal, Nicholson, Geoff and Berk, Michael. (2011). Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial. British Journal of Psychiatry. 198(5), pp. 357 - 364. https://doi.org/10.1192/bjp.bp.110.087544
Teriparatide therapy for osteonecrosis of the jaw REPLY
Cheung, Ada S. and Seeman, Ego. (2011). Teriparatide therapy for osteonecrosis of the jaw REPLY. New England Journal of Medicine. 364, pp. 1081 - 1082. https://doi.org/10.1056/NEJMc1100730
Annual feedback is an effective tool for a sustained increase in calcium intake among older women
Sanders, Kerrie, Stuart, Amanda L., Kotowicz, Mark and Nicholson, Geoff. (2010). Annual feedback is an effective tool for a sustained increase in calcium intake among older women. Nutrients. 2(9), pp. 1018 - 1025. https://doi.org/10.3390/nu2091018
Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial
Sanders, Kerrie, Stuart, Amanda L., Williamson, Elizabeth J., Simpson, Julie A., Kotowicz, Mark, Young, Doris and Nicholson, Geoff. (2010). Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA: Journal of the American Medical Association. 303(18), pp. 1815 - 1822. https://doi.org/10.1001/jama.2010.594
Festschrift to honor Professor Pierre D. Delmas
Seeman, E., Lindsay, R. and Kanis, J. A.. (2009). Festschrift to honor Professor Pierre D. Delmas. Osteoporosis International. 20(Supplement 3), pp. S231 - S233. https://doi.org/10.1007/s00198-008-0811-z
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
Kanis, John, Oden, Anders, Johnell, O., Johansson, Helena, Laet, C. De, Brown, Jacques P., Burckhardt, Peter, Cooper, Cyrus, Christiansen, Claus, Cummings, Steven R., Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, Didier, Krieg, Marc Antoine, Lacroix, Andrea Z., McCloskey, Eugene, Mellström, Dan, ... Yoshimura, N.. (2007). The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 18(8), pp. 1033 - 1046. https://doi.org/10.1007/s00198-007-0343-y
Bone fragility in men - Where are we?
Seeman, Ego, Bianchi, Georges, Khosla, Sundeep, Kanis, John and Orwoll, E. (2006). Bone fragility in men - Where are we? Osteoporosis International. 17(11), pp. 1577 - 1583. https://doi.org/10.1007/s00198-006-0160-8