Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion

Journal article


Gorissen, Stefan H. M., Burd, Nicholas A., Hamer, Henrike M., Gijsen, Annemie P., Groen, Bart B. L. and van Loon, Luc J. C.. (2014). Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. The Journal of Clinical Endocrinology and Metabolism. 99(6), pp. 2250 - 2258. https://doi.org/10.1210/jc.2013-3970
AuthorsGorissen, Stefan H. M., Burd, Nicholas A., Hamer, Henrike M., Gijsen, Annemie P., Groen, Bart B. L. and van Loon, Luc J. C.
Abstract

Background: Dietary protein digestion and absorption is an important factor modulating muscle protein accretion. However, there are few data available on the effects of coingesting other macronutrients with protein on digestion and absorption kinetics and the subsequent muscle protein synthetic response. Objective: The objective of the study was to determine the impact of carbohydrate coingestion with protein on dietary protein digestion and absorption and muscle protein accretion in healthy young and older men. Design: Twenty-four healthy young ( aged 21± 1 y, body mass index 21.8 ±0.5 kg/m2 ) and 25 older ( aged 75 ± 1 y, body mass index 25.4 ± 0.6 kg/m2 ) men received a primed continuous L-[ring-2H5]-phenylalanine and L-[ring-3,5-2H2]-tyrosine infusion and ingested 20 g intrinsically L-[1-13C]-phenylalanine-labeled protein with ( Pro+CHO ) or without ( Pro ) 60 g carbohydrate. Plasma samples and muscle biopsies were collected in a postabsorptive and postprandial state. Results: Carbohydrate coingestion delayed the appearance of exogenous phenylalanine in the circulation ( P = .001 ). Dietary protein-derived phenylalanine availability over the 5-hour postprandial period was lower in the older ( 62 ± 2% ) when compared with the young subjects ( 74 ± 2%; P = .007 ), with no differences between conditions ( P = .20 ). Carbohydrate coingestion did not modulate postprandial muscle protein synthesis rates ( 0.035 ± 0.003 vs 0.043 ± 0.004 and 0.033 ± 0.002 vs 0.035 ± 0.003%/h after Pro vs Pro+CHO in the young and older group, respectively ). In accordance, no differences in muscle protein-bound L-[1-13C]-phenylalanine enrichments were observed between conditions ( 0.020 ± 0.002 vs 0.020 ± 0.002 and 0.019 ± 0.003 vs 0.022 ± 0.004 mole percent excess after Pro vs Pro+CHO in the young and older subjects, respectively ). Conclusion: Carbohydrate coingestion with protein delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion in healthy young or older men.

Year2014
JournalThe Journal of Clinical Endocrinology and Metabolism
Journal citation99 (6), pp. 2250 - 2258
PublisherOxford University Press
ISSN0021-972X
Digital Object Identifier (DOI)https://doi.org/10.1210/jc.2013-3970
Scopus EID2-s2.0-84902310642
Page range2250 - 2258
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States
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