Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: Protocol for a randomised controlled trial

Journal article


O'Grady, Kerry-Ann F., Grimwood, Keith, Toombs, Maree, Sloots, Theo, Otim, Michael, Whiley, David, Anderson, Jennie, Rablin, Sheree, Torzillo, Paul J., Buntain, Helen, Connor, Anne, Adsett, Don, Kar, Oon Meng and Chang, Anne. (2017). Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: Protocol for a randomised controlled trial. BMJ Open. https://doi.org/10.1136/bmjopen-2016-013796
AuthorsO'Grady, Kerry-Ann F., Grimwood, Keith, Toombs, Maree, Sloots, Theo, Otim, Michael, Whiley, David, Anderson, Jennie, Rablin, Sheree, Torzillo, Paul J., Buntain, Helen, Connor, Anne, Adsett, Don, Kar, Oon Meng and Chang, Anne
Abstract

Introduction Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic ( > 4 weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care. Methods and analysis A multicentre, parallel group, open-label, randomised controlled trial, nested within a prospective cohort study in Southeast Queensland, Australia, is underway. 750 children aged < 15 years will be enrolled and followed weekly for 8 weeks after presenting with an ARI with cough. 214 children from this cohort with persistent cough at day 28 will be randomised to either early initiation of a cough management algorithm or usual care (107 per group). Randomisation is stratified by reason for presentation, site and total cough duration at day 28 ( < 6 and ≥6 weeks). Demographic details, risk factors, clinical histories, examination findings, cost-of-illness data, an anterior nasal swab and parent and child exhaled carbon monoxide levels (when age appropriate) are collected at enrolment. Weekly contacts will collect cough status and cost-of-illness data. Additional nasal swabs are collected at days 28 and 56. The primary outcome is time-to-cough resolution. Secondary outcomes include direct and indirect costs of illness and the predictors of chronic cough postpresentation.

Year2017
JournalBMJ Open
Digital Object Identifier (DOI)https://doi.org/10.1136/bmjopen-2016-013796
Scopus EID2-s2.0-85014908281
Open accessOpen access
Research GroupSchool of Allied Health
Publisher's version
Permalink -

https://acuresearchbank.acu.edu.au/item/85wqw/effectiveness-of-a-cough-management-algorithm-at-the-transitional-phase-from-acute-to-chronic-cough-in-australian-children-aged-15-years-protocol-for-a-randomised-controlled-trial

  • 82
    total views
  • 79
    total downloads
  • 3
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Towards best practice in acute stroke care in Ghana: A survey of hospital services
Baatiema, Leonard, Otim, Michael, Mnatzaganian, George, de-Graft Aikins, Ama, Coombes, Judith and Somerset, Shawn. (2017). Towards best practice in acute stroke care in Ghana: A survey of hospital services. BMC Health Services Research. 17(1), pp. 1 - 11. https://doi.org/10.1186/s12913-017-2061-2
Health professionals' views on the barriers and enablers to evidence-based practice for acute stroke care: A systematic review
Baatiema, Leonard, Otim, Michael E., Mnatzaganian, George, de-Graft Aikins, Ama, Coombes, Judith and Somerset, Shawn. (2017). Health professionals' views on the barriers and enablers to evidence-based practice for acute stroke care: A systematic review. Implementation Science. 12(1), pp. 1 - 15. https://doi.org/10.1186/s13012-017-0599-3
The effect of payment and incentives on motivation and focus of community health workers: five case studies from low- and middle-income countries
Singh, Debra, Negin, Joel, Otim, Michael, Orach, Christopher Garimoi and Cumming, Robert. (2015). The effect of payment and incentives on motivation and focus of community health workers: five case studies from low- and middle-income countries. Human Resources for Health. 13(1), pp. 1 - 12. https://doi.org/10.1186/s12960-015-0051-1
Acceptability of Program Budgeting and Marginal Analysis as a tool for routine priority-setting in Indigenous health
Otim, Michael E., Asante, Augustine D., Kelaher, Margaret, Anderson, Ian P. and Jan, Stephen. (2015). Acceptability of Program Budgeting and Marginal Analysis as a tool for routine priority-setting in Indigenous health. International Journal of Health Planning and Management. https://doi.org/10.1002/hpm.2287
What constitutes benefit from health care interventions for Indigenous Australians?
Otim, Michael E., Asante, Augustine D., Kelaher, Margaret, Doran, Chris M. and Anderson, Ian P.. (2015). What constitutes benefit from health care interventions for Indigenous Australians? Australian Aboriginal Studies.
Building evidence for peer led interventions: Assessing the cost of Adolescent Asthma Action program in Australia
Otim, Michael E., Jayasinha, Ranmalie, Forbes, Hayley and Shah, Smita. (2015). Building evidence for peer led interventions: Assessing the cost of Adolescent Asthma Action program in Australia. Australian Journal of Primary Health: the issues influencing community health services and primary health care (online version). 21(4), pp. 1 - 6. https://doi.org/10.1071/PY14066
The respiratory health of urban Indigenous children aged less than 5 years: study protocol for a prospective cohort study
Hall, Kerry K., Chang, Anne B., Sloots, Theo P., Anderson, Jennie, Kemp, Anita, Hammil, Jan, Otim, Michael and O'Grady, Kerry-Ann F.. (2015). The respiratory health of urban Indigenous children aged less than 5 years: study protocol for a prospective cohort study. BMC Pediatrics. 15(56), pp. 1 - 8. https://doi.org/10.1186/s12887-015-0375-y
Retaining doctors in rural Timor-Leste: A critical appraisal of opportunities and challenges
Asante, Augustine D., Martins, Nelson, Otim, Michael Ekubu and Dewdney, John. (2014). Retaining doctors in rural Timor-Leste: A critical appraisal of opportunities and challenges. Bulletin of World Health Organisation. 92(4), pp. 277 - 282. https://doi.org/10.2471/BLT.13.123141
Priority setting in Indigenous health : Assessing priority setting process and criteria that should guide the health system to improve Indigenous Australian health
Otim, Michael, Kelaher, Margaret, Anderson, Ian and Doran, Chris. (2014). Priority setting in Indigenous health : Assessing priority setting process and criteria that should guide the health system to improve Indigenous Australian health. International Journal for Equity in Health. 13(45), pp. 1 - 12. https://doi.org/10.1186/1475-9276-13-45
How much does intellectual disability really cost? First estimates for Australia
Doran, Christopher M., Einfeld, Stewart L., Madden, Rosamond H., Otim, Michael Ekubu, Horstead, Sian K., Ellis, Louise A. and Emerson, Eric. (2012). How much does intellectual disability really cost? First estimates for Australia. Journal of Intellectual and Developmental Disability. 37(1), pp. 42 - 49. https://doi.org/10.3109/13668250.2011.648609
Linking acute care to a strategy for improving Aboriginal health
Anderson, Ian P., Clarke, Angela, Reinhard, Russell, Otim, Michael and Andrews, Shawana. (2002). Linking acute care to a strategy for improving Aboriginal health. Australian Health Review. 25(5), pp. 118 - 129. https://doi.org/10.1071/AH020118