Endothelial precursor cells home to a vascularized tissue engineering chamber by application of the angiogenic chemokine cxcl12

Journal article


Simcock, Jeremy W., Penington, Anthony, Morrison, Wayne A., Thompson, Erik W. and Mitchell, Geraldine. (2009). Endothelial precursor cells home to a vascularized tissue engineering chamber by application of the angiogenic chemokine cxcl12. Tissue Engineering Part A: Tissue Engineering. 15(3), pp. 655 - 664. https://doi.org/10.1089/ten.tea.2007.0438
AuthorsSimcock, Jeremy W., Penington, Anthony, Morrison, Wayne A., Thompson, Erik W. and Mitchell, Geraldine
Abstract

Tissue engineering of vascularized constructs has great utility in reconstructive surgery. While we have been successful in generating vascularized granulation-like tissue and adipose tissue in an in vivo tissue engineering chamber, production of other differentiated tissues in a stable construct remains a challenge. One approach is to utilize potent differentiation factors, which can influence the base tissue. Endothelial precursor cells (EPCs) have the ability to both carry differentiation factors and home to developing vasculature. In this study, proof-of-principle experiments demonstrate that such cells can be recruited from the circulation into an in vivo tissue engineering chamber. CXC chemokine ligand 12 (CXCL12)/stromal cell–derived factor 1 was infused into the chamber through Alzet osmotic pumps and chamber cannulation between days 0 and 7, and facilitated recruitment of systemically inoculated exogenous human EPCs injected on day 6. CXCL12 infusion resulted in an eightfold increase in EPC recruitment, 2 (p = 0.03) and 7 days postinfusion (p = 0.008). Delivery of chemotactic/proliferation and/or differentiation factors and appropriately timed introduction of effective cells may allow us to better exploit the regenerative potential of the established chamber construct.

Year2009
JournalTissue Engineering Part A: Tissue Engineering
Journal citation15 (3), pp. 655 - 664
PublisherMary Ann Liebert, Inc. Publishers
ISSN1937-3341
Digital Object Identifier (DOI)https://doi.org/10.1089/ten.tea.2007.0438
Page range655 - 664
Place of publicationUnited States of America
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