Pearce, A., Clark, R. & Kidgell, D. (2013). A comparison of two methods in acquiring stimulus : Response curves with transcranial magnetic stimulation. Brain Stimulation: basic, translational and clinical research in neuromodulation,(3), 306-309. Retrieved from https://doi.org/10.1016/j.brs.2012.05.010
The stimulus–response (S–R) curve is a well accepted constituent in transcranial magnetic stimulation (TMS) studies. However, it has been suggested that parameters of the S–R curve differ when stimuli are provided in a “ramped” (measured steps from low to high intensity), or “random” fashion.
We hypothesized that there would be no difference in the parameters of the S–R curve between either methodologies.
Using a randomised cross-over design, 10 healthy participants (29.6 ± 6.4 yrs, 3 f) completed “ramped” or “random” curves in biceps brachii (BB) and first dorsal interosseous (FDI) muscles of both limbs. Curves were compared using mixed-factor ANOVA and correlated between limbs and methodologies.
No differences (P > 0.05) and high correlations (range 0.71–0.97; P < 0.001) were observed in BB and FDI data between curves.
This study demonstrated that either methodology provides similar parameters of the S–R curve in healthy participants.
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